Michael Barbella, Managing Editor07.19.22
Miniature robots may be deployed in the future to treat strokes.
The new treatment—using a magnetically controlled microrobot-enabled self-clearing catheter—has been 86% effective in animal models, according to a paper published in Nature Communications.
Hyowon "Hugh" Lee, a Purdue University associate professor from the Weldon School of Biomedical Engineering, created the magnetically controlled microdevice that removes blood accumulating in the brain during a stroke. The innovation was tested on porcine models of hemorrhage in collaboration with neurosurgeons Dr. Timothy Bentley from Purdue's College of Veterinary Medicine and Dr. Albert Lee from Goodman Campbell Brain and Spine in Carmel, Ind.
The microrobots successfully removed the blood in six of the seven animals in the treatment animal model.
"This innovation is a real advance in the care of strokes, which are notoriously difficult to treat," Hugh Lee said.
The current gold standard to treat strokes is a blood thinner called tissue plasminogen activator, which cannot be used for some hemorrhagic strokes.
"Patients with brain hemorrhages have a mortality rate of up to 50%," Albert Lee said. "Currently there is no great therapeutic solution for intraventricular hemorrhage. The only other option is blood clot-dissolving drugs that have undesirable risks."
Hugh Lee's innovation, which was developed with a former graduate student, Qi Yang, can be remotely activated using externally applied magnetic fields.
"There is no need for an implanted power source or complicated integrated circuit," Hugh Lee said. "As you change the direction of the magnetic field, the microdevice moves like a compass needle with a magnet nearby. They can be part of an implantable shunt system or a part of extraventricular drainage systems."
Hugh Lee disclosed the innovation to the Purdue Research Foundation Office of Technology Commercialization, which has filed for a patent on the intellectual property. The next step to further develop the device is to receive approval from the U.S. Food and Drug Administration for a first-in-human study.
Lee's collaborative research was funded by grants from the Indiana Clinical and Translational Sciences Institute and the National Institutes of Health.
Purdue University is a top public research institution developing practical solutions to today’s toughest challenges. Ranked in each of the last four years as one of the 10 Most Innovative universities in the United States by U.S. News & World Report, Purdue delivers world-changing research and out-of-this-world discovery.
The new treatment—using a magnetically controlled microrobot-enabled self-clearing catheter—has been 86% effective in animal models, according to a paper published in Nature Communications.
Hyowon "Hugh" Lee, a Purdue University associate professor from the Weldon School of Biomedical Engineering, created the magnetically controlled microdevice that removes blood accumulating in the brain during a stroke. The innovation was tested on porcine models of hemorrhage in collaboration with neurosurgeons Dr. Timothy Bentley from Purdue's College of Veterinary Medicine and Dr. Albert Lee from Goodman Campbell Brain and Spine in Carmel, Ind.
The microrobots successfully removed the blood in six of the seven animals in the treatment animal model.
"This innovation is a real advance in the care of strokes, which are notoriously difficult to treat," Hugh Lee said.
The current gold standard to treat strokes is a blood thinner called tissue plasminogen activator, which cannot be used for some hemorrhagic strokes.
"Patients with brain hemorrhages have a mortality rate of up to 50%," Albert Lee said. "Currently there is no great therapeutic solution for intraventricular hemorrhage. The only other option is blood clot-dissolving drugs that have undesirable risks."
Hugh Lee's innovation, which was developed with a former graduate student, Qi Yang, can be remotely activated using externally applied magnetic fields.
"There is no need for an implanted power source or complicated integrated circuit," Hugh Lee said. "As you change the direction of the magnetic field, the microdevice moves like a compass needle with a magnet nearby. They can be part of an implantable shunt system or a part of extraventricular drainage systems."
Hugh Lee disclosed the innovation to the Purdue Research Foundation Office of Technology Commercialization, which has filed for a patent on the intellectual property. The next step to further develop the device is to receive approval from the U.S. Food and Drug Administration for a first-in-human study.
Lee's collaborative research was funded by grants from the Indiana Clinical and Translational Sciences Institute and the National Institutes of Health.
Purdue University is a top public research institution developing practical solutions to today’s toughest challenges. Ranked in each of the last four years as one of the 10 Most Innovative universities in the United States by U.S. News & World Report, Purdue delivers world-changing research and out-of-this-world discovery.