• Login
    • Join
  • FOLLOW:
  • Subscribe Free
    • Magazine
    • eNewsletter
    Checkout
    • Magazine
    • News
    • Opinions
    • Top 30
    • Research
    • Supply Chain
    • Device Sectors
    • Directory
    • Events
    • Resources
    • Microsites
    • More
  • Magazine
  • News
  • Opinions
  • Top 30
  • Research
  • Supply Chain
  • Device Sectors
  • Directory
  • Events
  • Resources
  • Microsites
  • Current / Back Issues
    Features
    Editorial
    Digital Edition
    eNewsletter Archive
    Our Team
    Editorial Guidelines
    Reprints
    Subscribe Now
    Advertise Now
    Top Features
    Computer Concepts for Medical Device Design

    IVD Manufacturers Are Being Put to the Test

    The New State of Medtech Outsourcing

    The Changing Face of Medtech Surface Treatment

    The Totally Tubular Technologies that Support Medical Devices
    OEM News
    Supplier News
    Service / Press Releases
    Online Exclusives
    Press Releases
    People in the News
    Product & Service Releases
    Supplier News
    Medtech Makers
    Technical Features
    International News
    Videos
    Product & Service Releases
    Live From Shows
    Regulatory
    Financial/Business
    Top News
    CardioRenal’s TENOR Device Receives Breakthrough Device Designation from FDA

    LifeQ Unveils New 24-Hour Sleep Solution

    Babson Diagnostics Welcomes New Clinical Advisor, Andrew Carroll

    EvoEndo Names CEO and Chief Operating Officer

    Electromedical Products International Forms Scientific Advisory Board
    From the Editor
    Blogs
    Guest Opinions
    Top Opinions
    Computer Concepts for Medical Device Design

    IVD Manufacturers Are Being Put to the Test

    The New State of Medtech Outsourcing

    The Changing Face of Medtech Surface Treatment

    The Totally Tubular Technologies that Support Medical Devices
    Top 30 Medical Device Companies
    Market Data
    White Papers
    Top Research
    Checking Up on Surgical Robotics

    Building a Network: How Synchron Is Developing a New Device—and a New Market

    Six Lessons Learned on Developing a Strong Company Culture

    As Hiring Slows, Companies Look Inward to Fulfill Talent Needs

    Artificial Intelligence: Medtech Opportunity or Health Danger?
    3D/Additive Manufacturing
    Contract Manufacturing
    Electronics
    Machining & Laser Processing
    Materials
    Molding
    Packaging & Sterilization
    R&D & Design
    Software & IT
    Testing
    Tubing & Extrusion
    Cardiovascular
    Diagnostics
    Digital Health
    Neurological
    Patient Monitoring
    Surgical
    Orthopedics
    All Companies
    Categories
    Company Capabilities
    Add New Company
    Outsourcing Directory
    NDH Medical Inc.

    Medbio LLC

    LEMO USA Inc.

    Fusion Biotec Inc.

    Halkey-Roberts Corporation
    MPO Summit
    Industry Events
    Webinars
    Live From Show Event
    Industry Associations
    Videos
    Career Central
    eBook
    Slideshows
    Top Resources
    6 Considerations for Companies on the Cusp of Being Acquired

    3 Key Elements to Consider When Managing a Medtech Sales Force

    Tech-Enabled Virtual Speech Therapy Improves Speech & Communication Skills

    Practical Strategies for Digitization and Integration in Medtech Manufacturing

    Sensors: The Heart of Minimally Invasive Equipment Technology
    Companies
    News Releases
    Product Releases
    Press Releases
    Product Spec Sheets
    Service Releases
    Case Studies
    White Papers
    Brochures
    Videos
    Outsourcing Directory
    NDH Medical Inc.

    Medbio LLC

    LEMO USA Inc.

    Fusion Biotec Inc.

    Halkey-Roberts Corporation
    • Magazine
      • Current/Back Issues
      • Features
      • Editorial
      • Columns
      • Digital Editions
      • Subscribe Now
      • Advertise Now
    • News
    • Directory
      • All Companies
      • ALL CATEGORIES
      • Industry Associations
      • Company Capabilities
      • Add Your Company
    • Supply Chain
      • 3D/Additive Manufacturing
      • Contract Manufacturing
      • Electronics
      • Machining & Laser Processing
      • Materials
      • Molding
      • Packaging & Sterilization
      • R&D & Design
      • Software & IT
      • Testing
      • Tubing & Extrusion
    • Device Sectors
      • Cardiovascular
      • Diagnostics
      • Digital Health
      • Neurological
      • Patient Monitoring
      • Surgical
      • Orthopedics
    • Top 30 Company Report
    • Expert Insights
    • Slideshows
    • Videos
    • eBook
    • Resources
    • Podcasts
    • Infographics
    • Whitepapers
    • Research
      • White Papers
      • Case Studies
      • Product Spec Sheets
      • Market Data
    • MPO Summit
    • Events
      • Industry Events
      • Live From Show Events
      • Webinars
    • Microsite
      • Companies
      • Product Releases
      • Product Spec Sheets
      • Services
      • White Papers / Tech Papers
      • Press Releases
      • Videos
      • Literature / Brochures
      • Case Studies
    • About Us
      • About Us
      • Contact Us
      • Advertise with Us
      • eNewsletter Archive
      • Privacy Policy
      • Terms of Use
    Breaking News

    New Blood Test Offers Early Warning of Kidney Transplant Rejection

    KU Leuven kidney specialists develop a non-invasive biomarker for detection of rejection.

    New Blood Test Offers Early Warning of Kidney Transplant Rejection
    KU Leuven08.02.19
    A group of European scientists led by KU Leuven has found a biomarker that can identify patients with symptoms of kidney rejection symptoms after a transplant as a result of antibodies. The identification can be done through a simple blood test and at an early stage. It is the first known biomarker for rejection by antibodies. The researchers hope that the test can be further developed quickly for use in the hospital.
     
    After a kidney transplant, patients have to take medication to suppress their immune system. However, kidney rejections occur frequently. To determine if the body is rejecting the organ, doctors usually take a biopsy: using a needle, they remove a small piece of tissue from the transplanted kidney and examine it under a microscope. This procedure is often uncomfortable. Moreover, rejection symptoms are often discovered too late, so that correct treatment is not always possible anymore.
     
    At the University Hospitals Leuven in Belgium, kidney transplant patients systematically undergo a kidney biopsy three months, one year, and two years after the transplant. However, the biopsy only can detect rejection symptoms that are present at that moment, while rejection can occur at any time. Moreover, about ten to twenty percent of rejections remain undetected with current methods, which leads to graft failure, reinitiation of dialysis and the need for a repeat transplant.
     
    Milestone in Kidney Transplant Research
    For several years, kidney transplantation research has focused on finding biomarkers that can detect symptoms of organ rejection in the blood. Such a biomarker has now been discovered in a European study in four university hospitals (Leuven, Paris, Hannover and Limoges) that was spearheaded by nephrologists from KU Leuven.
     
    It is the first time that researchers have found a biomarker for kidney transplant rejection by antibodies. For T cell-mediated rejection, a common type of rejection, some biomarkers in the blood have recently been found, which are now being further developed for clinical use. Rejection by T cells is treatable, but there are fewer treatment options for rejection with antibodies.
     
    "Rejection by HLA antibodies often has serious consequences," said professor Maarten Naesens, nephrologist at the University Hospitals Leuven and principal investigator of the study. "Traditional tests for assessing the function of transplanted kidneys can often only identify rejection when it is already chronic and irreversible. Thanks to our biomarker, we can detect rejection much earlier and with a simple blood test. Because the test is less invasive, we will be able to test more often than with the current biopsies."
     
    Clinical Value
    In the first phase, the European researchers performed a genome-wide study to find out differences in RNA molecules among 117 patients with and without kidney rejection symptoms after a transplant. In the second phase, the different molecules of an independent group of 183 patients were processed into a mathematical model. The final biomarker consists of eight RNA molecules that are measured with an RT-PCR technique. In the third phase, the biomarker was validated in 387 patients in four European academic hospitals.
     
    "In addition to developing the biomarker, that third phase was very important," said Dr. Elisabet Van Loon from the Nephrology and Kidney Transplantation research group at KU Leuven. "Researchers are often satisfied with a new discovery, even though they are unable to test it in independent clinical studies. Thanks to international cooperation, we could validate our biomarker in a large group of patients. That gives us a lot of confidence in the clinical value of the new biomarker. "
     
    The researchers now want to consult with medical diagnostic companies to further develop and standardize the test. "In principle, our antibody rejection test has been sufficiently validated for commercialization," said Professor Naesens. "This is the next and necessary step to be able to offer the test to patients. With the test, patients who have no rejection of antibodies will no longer have to undergo a biopsy. The biomarker will also help to detect rejection sooner and will support the search for better medicines against rejection by antibodies."
     
    Find more information on the study here.
    Related Searches
    • needle
    • first
    • clinical studies
    • blood test
    Related Knowledge Center
    • Diagnostics
    Suggested For You
    Baxter, bioMérieux Ink Distribution Deal for Kidney Injury Dx Test Baxter, bioMérieux Ink Distribution Deal for Kidney Injury Dx Test
    FDA Greenlights First Blood Test for Novel Red Meat Allergy FDA Greenlights First Blood Test for Novel Red Meat Allergy
    Abbott’s COVID-19 Antibody Blood Test Gains EUA for Use on Alinity i System Abbott’s COVID-19 Antibody Blood Test Gains EUA for Use on Alinity i System
    Baxter’s Q1 Earnings Forecasted to Increase, GlobalData Says Baxter’s Q1 Earnings Forecasted to Increase, GlobalData Says
    Blood Test May Help Doctors Catch Pancreatic Cancer Early Blood Test May Help Doctors Catch Pancreatic Cancer Early
    Hydration Sensor Could Improve Dialysis Hydration Sensor Could Improve Dialysis
    CVS Health Begins Home Hemodialysis Trial CVS Health Begins Home Hemodialysis Trial
    New TB Blood Test May Also Identify People at Most Risk New TB Blood Test May Also Identify People at Most Risk
    New Technology May Lead to Implantable Artificial Kidneys New Technology May Lead to Implantable Artificial Kidneys
    CarThera Receives FDA Approval for Phase 1/2a Trial in Glioblastoma CarThera Receives FDA Approval for Phase 1/2a Trial in Glioblastoma
    Fiber-Optic Probe Could Continuously Measure Cardiac Flow During Surgery Fiber-Optic Probe Could Continuously Measure Cardiac Flow During Surgery
    Roche & Lund University Partner on Alzheimer Roche & Lund University Partner on Alzheimer's Blood Test
    New Blood Test Uses DNA ‘Packaging’ Patterns to Detect Multiple Cancer Types New Blood Test Uses DNA ‘Packaging’ Patterns to Detect Multiple Cancer Types
    Electric Field-Based Dressing Helps Heal Wound Infections Electric Field-Based Dressing Helps Heal Wound Infections
    For the First Time, Drone Flies Kidney to Patient for Successful Transplant For the First Time, Drone Flies Kidney to Patient for Successful Transplant

    Related Breaking News

    • Diagnostics
      Baxter, bioMérieux Ink Distribution Deal for Kidney Injury Dx Test

      Baxter, bioMérieux Ink Distribution Deal for Kidney Injury Dx Test

      Recent study highlights role of biomarker in predicting persistent severe acute kidney injury.
      Business Wire 09.16.20

    • Diagnostics
      FDA Greenlights First Blood Test for Novel Red Meat Allergy

      FDA Greenlights First Blood Test for Novel Red Meat Allergy

      Thermo Fisher's test helps pinpoint potentially fatal allergy often resulting from tick bites.
      PR Newswire 07.24.20

    • Diagnostics
      Abbott’s COVID-19 Antibody Blood Test Gains EUA for Use on Alinity i System

      Abbott’s COVID-19 Antibody Blood Test Gains EUA for Use on Alinity i System

      Plans to ship nearly 30 million antibody tests globally in May across its Architect and Alinity i platforms.
      PR Newswire 05.11.20


    • Baxter’s Q1 Earnings Forecasted to Increase, GlobalData Says

      Baxter’s Q1 Earnings Forecasted to Increase, GlobalData Says

      Job postings triple as demand increases.
      GlobalData 04.17.20

    • Diagnostics
      Blood Test May Help Doctors Catch Pancreatic Cancer Early

      Blood Test May Help Doctors Catch Pancreatic Cancer Early

      Penn study shows liquid biopsy may be viable option for both diagnosis and disease staging.
      Penn Medicine 04.16.20

    Loading, Please Wait..

    Trending
    • Healthcare Changes Prompt Medtronic To Merge Sales Force Medtronic, Inc. Is Combining Its U.S. Ca
    • Philips Names New Supervisory Board Chairman
    • A New Approach To Post-Market Surveillance
    • FDA Clears Sanara MedTech's Advanced Surgical Solution
    • Titan Medical Licenses Most IP To Intuitive; CEO Steps Down
    Breaking News
    • CardioRenal’s TENOR Device Receives Breakthrough Device Designation from FDA
    • LifeQ Unveils New 24-Hour Sleep Solution
    • Babson Diagnostics Welcomes New Clinical Advisor, Andrew Carroll
    • EvoEndo Names CEO and Chief Operating Officer
    • Electromedical Products International Forms Scientific Advisory Board
    View Breaking News >
    CURRENT ISSUE

    May 2023

    • Computer Concepts for Medical Device Design
    • IVD Manufacturers Are Being Put to the Test
    • The New State of Medtech Outsourcing
    • View More >

    Cookies help us to provide you with an excellent service. By using our website, you declare yourself in agreement with our use of cookies.
    You can obtain detailed information about the use of cookies on our website by clicking on "More information”.

    • About Us
    • Privacy Policy
    • Terms And Conditions
    • Contact Us

    follow us

    Subscribe
    Nutraceuticals World

    Latest Breaking News From Nutraceuticals World

    Stefan Pasiakos, PhD, Selected to Lead NIH Office of Dietary Supplements
    Verdure Sciences Receives Award for Sustainable, Ethical Turmeric Sourcing
    BGG Receives Patent for Saw Palmetto ID Method
    Coatings World

    Latest Breaking News From Coatings World

    Indorama Ventures and Carbios Reaffirm Partnership to Build PET Biorecycling Plant
    AkzoNobel Powder Coatings Enhances Digital Services with Launch of My Interpon Portal
    PPG Opens Color Creation Lab with Chery Automobile in China
    Medical Product Outsourcing

    Latest Breaking News From Medical Product Outsourcing

    CardioRenal’s TENOR Device Receives Breakthrough Device Designation from FDA
    LifeQ Unveils New 24-Hour Sleep Solution
    Babson Diagnostics Welcomes New Clinical Advisor, Andrew Carroll
    Contract Pharma

    Latest Breaking News From Contract Pharma

    Terran Biosciences, Pierre Fabre Ink Exclusive Licensing Deal for Idazoxan
    ASM Research Chemicals Launches Development Packs for API Manufacturing
    WuXi Increases Manufacturing Capacity in Germany
    Beauty Packaging

    Latest Breaking News From Beauty Packaging

    L'Oréal North Asia President Discusses China's Consumer Sector Recovery & Premium Beauty Trends
    Kiehl’s Celebrates Pride by Supporting The Trevor Project
    L’Oréal & UNESCO Announce 2023 Laureates of the For Women in Science International Awards
    Happi

    Latest Breaking News From Happi

    Olay Rolls Out Sensitive Skin Line
    World Taste & Smell Association's June 6 Webinar Looks at Smell and Multisensory Design
    Azelis Americas Opens New Application Labs for Personal Care, Home Care and Industrial Cleaning
    Ink World

    Latest Breaking News From Ink World

    Mactac Acquires Canadian Roll Label Distributor Label Supply
    WestRock Advances its Commitment to a Sustainable Future
    Roland DGA Announces Key Service Department Personnel Changes
    Label & Narrow Web

    Latest Breaking News From Label & Narrow Web

    Schreiner's Pharma-Comb IL Label supports clinical trial cancer medication
    First Anytron ANY-JET III digital label press installed in Korea
    FPA announces Kasie Fairbarn as elected ELC co-chair
    Nonwovens Industry

    Latest Breaking News From Nonwovens Industry

    Harper Hygienics Launches Hemp-Based Intimate Care Wipes
    What You’re Reading on Nonwovens-Industry.com
    Biodiapers Signs Agreement with Sicam
    Orthopedic Design & Technology

    Latest Breaking News From Orthopedic Design & Technology

    Augmedics Debuts New Features, Indications for xvision Platform
    Artelon Closes $20M Series B Funding
    Orthofix Unveils Seven-Year Outcome Data for M6-C Artificial Cervical Disc
    Printed Electronics Now

    Latest Breaking News From Printed Electronics Now

    DIC Acquires Photoresist Polymers Manufacturer PCAS Canada
    Arkema Collaborates with Habitat for Humanity Philadelphia
    Vitesco Technologies, onsemi Sign SiC Long-Term Supply Agreement

    Copyright © 2023 Rodman Media. All rights reserved. Use of this constitutes acceptance of our privacy policy The material on this site may not be reproduced, distributed, transmitted, or otherwise used, except with the prior written permission of Rodman Media.

    AD BLOCKER DETECTED

    Our website is made possible by displaying online advertisements to our visitors.
    Please consider supporting us by disabling your ad blocker.


    FREE SUBSCRIPTION Already a subscriber? Login