• Login
    • Join
  • FOLLOW:
  • Subscribe Free
    • Magazine
    • eNewsletter
    Checkout
    • Magazine
    • News
    • Opinions
    • Top 30
    • Research
    • Supply Chain
    • Device Sectors
    • Directory
    • Events
    • Resources
    • Microsites
    • More
  • Magazine
  • News
  • Opinions
  • Top 30
  • Research
  • Supply Chain
  • Device Sectors
  • Directory
  • Events
  • Resources
  • Microsites
  • Current / Back Issues
    Features
    Editorial
    Digital Edition
    eNewsletter Archive
    Our Team
    Editorial Guidelines
    Reprints
    Subscribe Now
    Advertise Now
    Top Features
    Pharmaceutical Focus: A Look at Combination Products

    The Printed World: Additive Manufacturing in Medtech

    The Lost Year: 2020 Year in Review

    Extrusion Evolution

    Little Big Parts: Micromolding Under the Microscope
    OEM News
    Supplier News
    Service / Press Releases
    Online Exclusives
    Press Releases
    People in the News
    Product & Service Releases
    Supplier News
    Medtech Makers
    Technical Features
    International News
    Videos
    Product & Service Releases
    Live From Shows
    Top News
    Optimize EP Launches CaRM Cardiac Device Data Management Platform

    U.S. TAVR Market Projected to Reach Nearly $5 Billion by 2030

    FDA Clears Canon Medical's Compressed SPEEDER for 3D Exams on 1.5T MR

    Cognito Therapeutics’ Lead Product Receives FDA Breakthrough Device Designation

    Moon Surgical Expands Leadership Team
    From the Editor
    Blogs
    Guest Opinions
    Top Opinions
    Pharmaceutical Focus: A Look at Combination Products

    The Printed World: Additive Manufacturing in Medtech

    The Lost Year: 2020 Year in Review

    Extrusion Evolution

    Little Big Parts: Micromolding Under the Microscope
    Top 30 Medical Device Companies
    Market Data
    White Papers
    Top Research
    Fixing Face Mask Form and Function

    The Heart of the Matter: Trends in Cardiology

    Virtually the Same? The Challenges of Online Conferences

    Digital Health Delivers During a Year for the Ages

    Advanced Technology for Staking and Swaging Medical Plastics
    3D/Additive Manufacturing
    Contract Manufacturing
    Electronics
    Machining & Laser Processing
    Materials
    Molding
    Packaging & Sterilization
    R&D & Design
    Software & IT
    Testing
    Tubing & Extrusion
    Cardiovascular
    Diagnostics
    Digital Health
    Neurological
    Patient Monitoring
    Surgical
    Orthopedics
    All Companies
    Categories
    Company Capabilities
    Add New Company
    Outsourcing Directory
    K-Tube Technologies

    maxon

    Creganna Medical, part of TE Connectivity

    MW Life Sciences

    Element
    MPO Summit
    Industry Events
    Webinars
    Live From Show Event
    Industry Associations
    Videos
    Career Central
    eBook
    Slideshows
    Top Resources
    Meeting Critical Ventilator Product Requirements Amid Pandemic

    Impact of COVID-19 on the Medtech Supply Chain

    Finding the Upside to a Challenging Year

    Preparing Your Design Controls for FDA Approval

    A 'Trial and Error' Approach to Micromolded Parts
    Companies
    News Releases
    Product Releases
    Press Releases
    Product Spec Sheets
    Service Releases
    Case Studies
    White Papers
    Brochures
    Videos
    Outsourcing Directory
    maxon

    Medicoil

    Medbio LLC

    PTI Engineered Plastics Inc.

    FUTEK Advanced Sensor Technology Inc.
    • Magazine
      • Current/Back Issues
      • Features
      • Editorial
      • Columns
      • Digital Editions
      • Subscribe Now
      • Advertise Now
    • News
    • Directory
      • All Companies
      • ALL CATEGORIES
      • Industry Associations
      • Company Capabilities
      • Add Your Company
    • Supply Chain
      • 3D/Additive Manufacturing
      • Contract Manufacturing
      • Electronics
      • Machining & Laser Processing
      • Materials
      • Molding
      • Packaging & Sterilization
      • R&D & Design
      • Software & IT
      • Testing
      • Tubing & Extrusion
    • Device Sectors
      • Cardiovascular
      • Diagnostics
      • Digital Health
      • Neurological
      • Patient Monitoring
      • Surgical
      • Orthopedics
    • Top 30 Company Report
    • Expert Insights
    • Slideshows
    • Videos
    • Podcasts
    • Resources
    • eBook
    • Infographics
    • Whitepapers
    • Research
      • White Papers
      • Case Studies
      • Product Spec Sheets
      • Market Data
    • MPO Summit
    • Events
      • Industry Events
      • Live From Show Events
      • Webinars
    • Microsite
      • Companies
      • Product Releases
      • Product Spec Sheets
      • Services
      • White Papers / Tech Papers
      • Press Releases
      • Videos
      • Literature / Brochures
      • Case Studies
    • About Us
      • About Us
      • Contact Us
      • Advertise with Us
      • eNewsletter Archive
      • Privacy Policy
      • Terms of Use
    Breaking News

    Nanodiamonds Are an MRI's Best Friend

    Nanodiamond-enhanced MRI offers a greater range of diagnostic and therapeutic applications.

    Nanodiamonds Are an MRI
    Related CONTENT
    • 75-Minute Diagnostic Determines COVID Status
    • Varex Imaging Welcomes New Finance Chief
    • Smart E-Skin, Robotic Hand Could Gather Vital Diagnostic Data
    • FDA Clears KA Imaging’s Portable Dual-Energy X-Ray Detector
    • Turner Imaging Systems, Siemens Healthineers Forge New Business Relationship Agreement
    Massachusetts General Hospital04.26.17
    Nanodiamonds—synthetic industrial diamonds only a few nanometers in size—have recently attracted considerable attention because of the potential they offer for the targeted delivery of vaccines and cancer drugs and for other uses. Thus far, options for imaging nanodiamonds have been limited. Now a team of investigators based at the Athinoula A. Martinos Center for Biomedical Imaging at Massachusetts General Hospital has devised a means of tracking nanodiamonds noninvasively with magnetic resonance imaging (MRI), opening up a host of new applications. They reported their findings in the online journal Nature Communications.
     
    "With this study, we showed we could produce biomedically relevant MR images using nanodiamonds as the source of contrast in the images and that we could switch the contrast on and off at will," said David Waddington, lead author of the paper and a Ph.D. student at the University of Sydney in Australia. Waddington is currently working with Matthew Rosen, Ph.D., in the Low-Field Imaging Laboratory at the Martinos Center. "With competing strategies, the nanodiamonds must be prepared externally and then injected into the body, where they can only be imaged for a few hours at most. However, as our technique is biocompatible, we can continue imaging for indefinite periods of time. This raises the possibility of tracking the delivery of nanodiamond-drug compounds for a variety of diseases and providing vital information on the efficacy of different treatment options."
     
    Waddington began this work three years ago as part of a Fulbright Scholarship awarded early in his graduate work at the University of Sydney, where he is a member of a team led by study co-author David Reilly, Ph.D., in the new Sydney Nanoscience Hub—the headquarters of the Australian Institute for Nanoscale Science and Technology, which launched last year. As part of the Reilly group, Waddington played a crucial role in early successes with nanodiamond imaging, including a 2015 paper in Nature Communications. He then sought to extend the potential of the approach by collaborating with Rosen at the Martinos Center and Ronald Walsworth, Ph.D., at Harvard University, also a co-author of the current study. Rosen's group is a world leader in the area of ultra-low-field magnetic resonance imaging, a technique that proved essential to the development of in vivo nanodiamond imaging.
     
    Previously, the use of nanodiamond imaging in living systems was limited to regions accessible using optical fluorescence techniques. However, most potential diagnostic and therapeutic applications of nanoparticles, including tracking of complex disease processes like cancer, call for the use of MRI—the gold standard for noninvasive, high-contrast, three-dimensional clinical imaging.
     
    In the present study, the researchers show that they could achieve nanodiamond-enhanced MRI by taking advantage of a phenomenon known as the Overhauser effect to boost the inherently weak magnetic resonance signal of diamond through a process called hyperpolarization, in which nuclei are aligned inside a diamond so they create a signal detectable by an MRI scanner. The conventional approach to hyperpolarization uses solid-state physics techniques at cryogenic temperatures, but the signal boost doesn't last very long and is nearly gone by the time the nanoparticle compound is injected into the body. By combining the Overhauser effect with advances in ultra-low-field MRI coming out of the Martinos Center, the researchers were able to overcome this limitation—thus paving the way for high-contrast in vivo nanodiamond imaging over indefinitely long periods of time.
     
    High-performance ultra-low-field MRI is itself a relatively new technology, first reported in Scientific Reports in 2015 by Rosen and Martinos Center colleagues. "Thanks to innovative engineering, acquisition strategies and signal processing, the technology offers heretofore unattainable speed and resolution in the ultra-low-field MRI regime," said Rosen, director of the Low-Field Imaging Laboratory, an assistant professor of Radiology at Harvard Medical School and the senior author of the current paper. "And importantly, by removing the need for massive, cryogen-cooled superconducting magnets, it opens up a number of new opportunities, including the nanodiamond imaging technique we've just described."
     
    The researchers have noted several possible applications for their new approach to nanodiamond-enhanced MRI. These include the accurate detection of lymph node tumors, which can aid in the treatment of metastatic prostate cancer, and exploring the permeability of the blood-brain barrier, which can play an important role in the management of ischemic stroke. Because it provides a measurable MR signal for periods of over a month, the technique could benefit applications such as monitoring the response to therapy.
     
    Included in treatment monitoring are applications in the burgeoning field of personalized medicine. "The delivery of highly specific drugs is strongly correlated with successful patient outcomes," said Waddington, who was honored with the Journal of Magnetic Resonance Young Scientist Award at the 2016 Experimental NMR Conference in recognition of this work. "However, the response to such drugs often varies significantly on an individual basis. The ability to image and track the delivery of these nanodiamond-drug compounds would, therefore, be greatly advantageous to the development of personalized treatments."
     
    The researchers continue to explore the potential of the technique and are now planning a detailed study of the approach in an animal model, while also investigating the behavior of different nanodiamond-drug complexes and imaging them with the new capability.

    Find more information on the study here.
    Related Searches
    • development
    • blood
    • 2015
    • patient
    Related Knowledge Center
    • Diagnostics
    Suggested For You
    75-Minute Diagnostic Determines COVID Status 75-Minute Diagnostic Determines COVID Status
    Varex Imaging Welcomes New Finance Chief Varex Imaging Welcomes New Finance Chief
    Smart E-Skin, Robotic Hand Could Gather Vital Diagnostic Data Smart E-Skin, Robotic Hand Could Gather Vital Diagnostic Data
    FDA Clears KA Imaging’s Portable Dual-Energy X-Ray Detector FDA Clears KA Imaging’s Portable Dual-Energy X-Ray Detector
    Turner Imaging Systems, Siemens Healthineers Forge New Business Relationship Agreement Turner Imaging Systems, Siemens Healthineers Forge New Business Relationship Agreement
    Former EOS Imaging CEO Appointed to EDAP TMS Board Former EOS Imaging CEO Appointed to EDAP TMS Board
    FDA OKs B. Braun FDA OKs B. Braun's SpaceStation MRI
    Diagnostic May Bring Faster, Cheaper Cancer Testing to Remote Settings Diagnostic May Bring Faster, Cheaper Cancer Testing to Remote Settings
    Scientists Suggest Device to Make Breast MRI More Effective Scientists Suggest Device to Make Breast MRI More Effective
    Less-Than-One-Second COVID Diagnostic Test Developed Less-Than-One-Second COVID Diagnostic Test Developed
    Canon Medical, Surfacide Partner on Imaging Systems Decontamination Canon Medical, Surfacide Partner on Imaging Systems Decontamination
    Avicenna.AI Avicenna.AI's CINA Head Neurovascular Imaging AI Tool Earns FDA Nod
    Centogene Receives EUA for COVID-19 Molecular Diagnostic Test Centogene Receives EUA for COVID-19 Molecular Diagnostic Test
    FDA Approves Axonics FDA Approves Axonics' r-SNM System for 3T Full-Body MRI Scans
    How Are MPO’s Top 30 Addressing COVID-19? How Are MPO’s Top 30 Addressing COVID-19?

    Related Breaking News

    • Diagnostics
      Rapid Antigen Tests Manufacturer Acquires BIOLAB

      Rapid Antigen Tests Manufacturer Acquires BIOLAB

      Deal will create jobs and increase Innova's U.S. COVID-19 test kit manufacturing capability.
      Innova Medical Group Inc. 01.14.21

    • Diagnostics
      PerkinElmer

      PerkinElmer's SARS-CoV-2 RT-PCR Assay Earns EUA for Asymptomatic Testing

      Gold-standard testing of individuals without COVID-19 symptoms key to controlling the spread.
      Business Wire 01.14.21

    • Diagnostics
      High-Volume COVID Antigen Test Receives FDA EUA

      High-Volume COVID Antigen Test Receives FDA EUA

      Ortho’s Vitros can run up to 130 tests per hour and helps address testing backlogs, supply shortages, and delayed results.
      Ortho Clinical Diagnostics 01.13.21


    • Diagnostics
      Researchers Develop Chip That Can Detect COVID-19 Antibodies in a Minute

      Researchers Develop Chip That Can Detect COVID-19 Antibodies in a Minute

      New diagnostic platform could be a valuable tool for detecting exposure to multiple viruses.
      Bob Marcotte, University of Rochester 01.13.21

    • Diagnostics
      Abbott to Supply Additional 30M COVID-19 Tests to U.S. Gov

      Abbott to Supply Additional 30M COVID-19 Tests to U.S. Gov't

      Company is in final stages of completing its self-funded capacity expansion across U.S. manufacturing sites.
      PR Newswire 01.13.21

    • Diagnostics
      Olympus and Hitachi Sign Five-Year Contract

      Olympus and Hitachi Sign Five-Year Contract

      Will jointly develop Endoscopic Ultrasound Systems.
      Olympus Corporation 01.11.21


    • Diagnostics
      ForaCare Suisse AG Launches COVID-19 Antigen Rapid Test

      ForaCare Suisse AG Launches COVID-19 Antigen Rapid Test

      Provides fast, accurate, and easy-to-interpret test results.
      PRNewswire 01.11.21

    • Diagnostics | Neurological
      FDA OKs Abbott

      FDA OKs Abbott's First-of-Its-Kind Rapid, Handheld TBI Test

      Produces a result within 15 minutes after a plasma sample is inserted.
      Abbott Laboratories 01.11.21

    • Diagnostics
      SARS-CoV-2 Mutation Prompts FDA Alert

      SARS-CoV-2 Mutation Prompts FDA Alert

      Impact remains low, but false negative results can occur with any molecular test.
      U.S. Food and Drug Administration 01.11.21


    • Diagnostics
      CareDx Partners with IDbyDNA

      CareDx Partners with IDbyDNA

      Will develop AlloID, a transplant patient-specific metagenomic infectious disease test platform.
      Globe Newswire 01.08.21

    • Diagnostics
      Siemens Healthineers’ Laboratory-Based IL-6 Assay Receives EUA

      Siemens Healthineers’ Laboratory-Based IL-6 Assay Receives EUA

      Helps identify severe inflammatory immune responses in patients confirmed to have COVID-19.
      Siemens Healthineers 01.08.21

    • Diagnostics
      Quantitative Transmission Ultrasound Outperforms Mammography

      Quantitative Transmission Ultrasound Outperforms Mammography

      QT Imaging completes first-in-human study of transmission ultrasound as a new imaging technology for breast health screening.
      PRNewswire 01.07.21


    • Diagnostics
      University of Birmingham Researchers Invent New COVID-19 Test

      University of Birmingham Researchers Invent New COVID-19 Test

      Delivers accurate results within minutes.
      University of Birmingham 01.07.21

    • Chronic Disease | Diagnostics
      Hologic to Buy Cancer Test Maker Biotheranostics for $230M

      Hologic to Buy Cancer Test Maker Biotheranostics for $230M

      Accelerates Hologic’s entry into the oncology growth market, provides new lab capabilities.
      Business Wire 01.06.21

    • Diagnostics
      EKF Introduces Accurate Quantitative COVID-19 Antibody Test Kit

      EKF Introduces Accurate Quantitative COVID-19 Antibody Test Kit

      The test kit is one of first to detect both the presence and precise levels of COVID-19 neutralizing antibodies.
      EKF Diagnostics 01.05.21


    Trending
    • Cytotron Gains Breakthrough Status To Treat Breast, Liver, And Pancreatic Cancers
    • Portable, Home-Use Device Quickly Measures Inflammation Levels
    • Medtech Matters: Talking Robotic Surgery With Zimmer Biomet
    • 5 Ways Plastics Revolutionized The Healthcare Industry
    • Moon Surgical Expands Leadership Team
    Breaking News
    • Optimize EP Launches CaRM Cardiac Device Data Management Platform
    • U.S. TAVR Market Projected to Reach Nearly $5 Billion by 2030
    • FDA Clears Canon Medical's Compressed SPEEDER for 3D Exams on 1.5T MR
    • Cognito Therapeutics’ Lead Product Receives FDA Breakthrough Device Designation
    • Moon Surgical Expands Leadership Team
    View Breaking News >
    CURRENT ISSUE

    November/December 2020

    • Pharmaceutical Focus: A Look at Combination Products
    • The Printed World: Additive Manufacturing in Medtech
    • The Lost Year: 2020 Year in Review
    • View More >

    Cookies help us to provide you with an excellent service. By using our website, you declare yourself in agreement with our use of cookies.
    You can obtain detailed information about the use of cookies on our website by clicking on "More information”.

    • About Us
    • Privacy Policy
    • Terms And Conditions
    • Contact Us

    follow us

    Subscribe
    Nutraceuticals World

    Latest Breaking News From Nutraceuticals World

    Brown Fat Associated with Reductions in Chronic Disease Risk
    NIH Study Identifies Antibacterial Properties in Taurine
    NSF Begins New Certification Program
    Coatings World

    Latest Breaking News From Coatings World

    Zeppelin Acquires MTI Mischtechnik
    Ezio Braggio Joins ChemQuest Europe
    IFS Coatings Announce Carbon Offset Program
    Medical Product Outsourcing

    Latest Breaking News From Medical Product Outsourcing

    Optimize EP Launches CaRM Cardiac Device Data Management Platform
    U.S. TAVR Market Projected to Reach Nearly $5 Billion by 2030
    FDA Clears Canon Medical's Compressed SPEEDER for 3D Exams on 1.5T MR
    Contract Pharma

    Latest Breaking News From Contract Pharma

    KORSCH, MEDELPHARM Partner on R&D Equipment Portfolio
    Frontage Bolsters Clinical Services Capabilities
    Sanofi Unveils EUROAPI as Name of New European API Company
    Beauty Packaging

    Latest Breaking News From Beauty Packaging

    Neenah to Host Packaging Webinar for Printers
    W.S. Badger is Named a ‘150 Top Impact Company’
    Mana Products, Meiyume and RPG Form The Vertical Beauty Alliance
    Happi

    Latest Breaking News From Happi

    A Surge in Interest for Supplements & Vitamins
    P&G, L'Oréal & Amorepacific Make News at CES
    Three Form Vertical Beauty Alliance
    Ink World

    Latest Breaking News From Ink World

    dar-tech, inc. Becomes U.S. Midwestern Distributor for ZS Interpolymer
    Techkon USA, Konica Minolta Partner
    Alon Bar-Shany Appointed Chairman of Highcon Board
    Label & Narrow Web

    Latest Breaking News From Label & Narrow Web

    Exhibitor registration opens for virtual.drupa
    FTA planning in-person Forum & INFOFLEX
    Fortis Solutions Group achieves SGP certification
    Nonwovens Industry

    Latest Breaking News From Nonwovens Industry

    Shemesh Adds U.S. Headquarters
    TZMO USA, Special Needs Group Form Partnership
    BAHP Announces 2021 Officers, Board of Directors
    Orthopedic Design & Technology

    Latest Breaking News From Orthopedic Design & Technology

    Rapid Recovery Protocol Can Lead to Increased Range of Motion After TKA
    Boston Scientific Releases WaveWriter Alpha Spinal Cord Stimulators in U.S.
    New Chief Clinical Officer on Board at IncludeHealth
    Printed Electronics Now

    Latest Breaking News From Printed Electronics Now

    Roadsimple Modernizes Warehouse Ops with Zebra Technologies
    Toppan Announces 2050 Environmental Vision
    SOI Industry Consortium Joins SEMI as Strategic Association Partner

    Copyright © 2021 Rodman Media. All rights reserved. Use of this constitutes acceptance of our privacy policy The material on this site may not be reproduced, distributed, transmitted, or otherwise used, except with the prior written permission of Rodman Media.

    AD BLOCKER DETECTED

    Our website is made possible by displaying online advertisements to our visitors.
    Please consider supporting us by disabling your ad blocker.


    FREE SUBSCRIPTION Already a subscriber? Login