• Login
    • Join
  • FOLLOW:
  • Subscribe Free
    • Magazine
    • eNewsletter
    Checkout
    • Magazine
    • News
    • Opinions
    • Top 30
    • Research
    • Supply Chain
    • Device Sectors
    • Directory
    • Events
    • Resources
    • Microsites
    • More
  • Magazine
  • News
  • Opinions
  • Top 30
  • Research
  • Supply Chain
  • Device Sectors
  • Directory
  • Events
  • Resources
  • Microsites
  • Current / Back Issues
    Features
    Editorial
    Digital Edition
    eNewsletter Archive
    Our Team
    Editorial Guidelines
    Reprints
    Subscribe Now
    Advertise Now
    Top Features
    Cybersecurity Challenges Leave Medical Device Makers Insecure

    OEMs Are Demanding Designs that Challenge Suppliers

    Diabetes Technology Manufacturers Seemingly on a Sugar Rush

    Post-Pandemic Partnerships: A Full-Service Outsourcing Discussion

    Discovering the Value of Surface Treatments and Coatings for Medtech
    OEM News
    Supplier News
    Service / Press Releases
    Online Exclusives
    Press Releases
    People in the News
    Product & Service Releases
    Supplier News
    Medtech Makers
    Technical Features
    International News
    Videos
    Product & Service Releases
    Live From Shows
    Regulatory
    Financial/Business
    Top News
    Linear Health Sciences’ Orchid SRV Receives FDA & Health Canada Approval

    Vivasure Medical Raises $23 Million in Series D Financing Round

    New Patents Add Value to Know Labs' Bio-RFID Tech

    Ra Medical Granted Patent for Catheters With Expanded Ablation Area

    ReCor Medical Presents Data from Two Randomized Trials
    From the Editor
    Blogs
    Guest Opinions
    Top Opinions
    Cybersecurity Challenges Leave Medical Device Makers Insecure

    OEMs Are Demanding Designs that Challenge Suppliers

    Diabetes Technology Manufacturers Seemingly on a Sugar Rush

    Post-Pandemic Partnerships: A Full-Service Outsourcing Discussion

    Discovering the Value of Surface Treatments and Coatings for Medtech
    Top 30 Medical Device Companies
    Market Data
    White Papers
    Top Research
    Injecting Neurostimulators into Blood Vessels (We Swear, It’s Not Sci-Fi)

    Understanding the Costs of Care in the OR

    Sick of Being Sick: Pandemic Fatigue Flares at AAOS

    Managing Critical Healthcare Supply Chains in Turbulent Times

    To Drive Value, Human Capital Leaders Turn to Outsourced Solutions
    3D/Additive Manufacturing
    Contract Manufacturing
    Electronics
    Machining & Laser Processing
    Materials
    Molding
    Packaging & Sterilization
    R&D & Design
    Software & IT
    Testing
    Tubing & Extrusion
    Cardiovascular
    Diagnostics
    Digital Health
    Neurological
    Patient Monitoring
    Surgical
    Orthopedics
    All Companies
    Categories
    Company Capabilities
    Add New Company
    Outsourcing Directory
    Trademark Plastics Inc.

    Arthur G. Russell Co. Inc., The

    BMP Medical

    Xact Wire EDM Corp.

    Cirtec Medical
    MPO Summit
    Industry Events
    Webinars
    Live From Show Event
    Industry Associations
    Videos
    Career Central
    eBook
    Slideshows
    Top Resources
    3D Printing in Dental Prosthodontics, Orthodontics, and Surgery

    What New Tech Can Improve Your Medical Manufacturing Plant?

    Why Medical Device Firms Must Navigate the Muddy Waters of ESG Requirements

    Medical Device Servicing vs. Remanufacturing

    Digital Marketplaces for Medical Equipment Come of Age
    Companies
    News Releases
    Product Releases
    Press Releases
    Product Spec Sheets
    Service Releases
    Case Studies
    White Papers
    Brochures
    Videos
    Outsourcing Directory
    Trademark Plastics Inc.

    Arthur G. Russell Co. Inc., The

    BMP Medical

    Xact Wire EDM Corp.

    Cirtec Medical
    • Magazine
      • Current/Back Issues
      • Features
      • Editorial
      • Columns
      • Digital Editions
      • Subscribe Now
      • Advertise Now
    • News
    • Directory
      • All Companies
      • ALL CATEGORIES
      • Industry Associations
      • Company Capabilities
      • Add Your Company
    • Supply Chain
      • 3D/Additive Manufacturing
      • Contract Manufacturing
      • Electronics
      • Machining & Laser Processing
      • Materials
      • Molding
      • Packaging & Sterilization
      • R&D & Design
      • Software & IT
      • Testing
      • Tubing & Extrusion
    • Device Sectors
      • Cardiovascular
      • Diagnostics
      • Digital Health
      • Neurological
      • Patient Monitoring
      • Surgical
      • Orthopedics
    • Top 30 Company Report
    • Expert Insights
    • Slideshows
    • Videos
    • eBook
    • Resources
    • Podcasts
    • Infographics
    • Whitepapers
    • Research
      • White Papers
      • Case Studies
      • Product Spec Sheets
      • Market Data
    • MPO Summit
    • Events
      • Industry Events
      • Live From Show Events
      • Webinars
    • Microsite
      • Companies
      • Product Releases
      • Product Spec Sheets
      • Services
      • White Papers / Tech Papers
      • Press Releases
      • Videos
      • Literature / Brochures
      • Case Studies
    • About Us
      • About Us
      • Contact Us
      • Advertise with Us
      • eNewsletter Archive
      • Privacy Policy
      • Terms of Use
    Breaking News

    Nanodiamonds Are an MRI's Best Friend

    Nanodiamond-enhanced MRI offers a greater range of diagnostic and therapeutic applications.

    Nanodiamonds Are an MRI
    Related CONTENT
    • 75-Minute Diagnostic Determines COVID Status
    • Varex Imaging Welcomes New Finance Chief
    • Smart E-Skin, Robotic Hand Could Gather Vital Diagnostic Data
    • FDA Clears KA Imaging’s Portable Dual-Energy X-Ray Detector
    • Turner Imaging Systems, Siemens Healthineers Forge New Business Relationship Agreement
    Massachusetts General Hospital04.26.17
    Nanodiamonds—synthetic industrial diamonds only a few nanometers in size—have recently attracted considerable attention because of the potential they offer for the targeted delivery of vaccines and cancer drugs and for other uses. Thus far, options for imaging nanodiamonds have been limited. Now a team of investigators based at the Athinoula A. Martinos Center for Biomedical Imaging at Massachusetts General Hospital has devised a means of tracking nanodiamonds noninvasively with magnetic resonance imaging (MRI), opening up a host of new applications. They reported their findings in the online journal Nature Communications.
     
    "With this study, we showed we could produce biomedically relevant MR images using nanodiamonds as the source of contrast in the images and that we could switch the contrast on and off at will," said David Waddington, lead author of the paper and a Ph.D. student at the University of Sydney in Australia. Waddington is currently working with Matthew Rosen, Ph.D., in the Low-Field Imaging Laboratory at the Martinos Center. "With competing strategies, the nanodiamonds must be prepared externally and then injected into the body, where they can only be imaged for a few hours at most. However, as our technique is biocompatible, we can continue imaging for indefinite periods of time. This raises the possibility of tracking the delivery of nanodiamond-drug compounds for a variety of diseases and providing vital information on the efficacy of different treatment options."
     
    Waddington began this work three years ago as part of a Fulbright Scholarship awarded early in his graduate work at the University of Sydney, where he is a member of a team led by study co-author David Reilly, Ph.D., in the new Sydney Nanoscience Hub—the headquarters of the Australian Institute for Nanoscale Science and Technology, which launched last year. As part of the Reilly group, Waddington played a crucial role in early successes with nanodiamond imaging, including a 2015 paper in Nature Communications. He then sought to extend the potential of the approach by collaborating with Rosen at the Martinos Center and Ronald Walsworth, Ph.D., at Harvard University, also a co-author of the current study. Rosen's group is a world leader in the area of ultra-low-field magnetic resonance imaging, a technique that proved essential to the development of in vivo nanodiamond imaging.
     
    Previously, the use of nanodiamond imaging in living systems was limited to regions accessible using optical fluorescence techniques. However, most potential diagnostic and therapeutic applications of nanoparticles, including tracking of complex disease processes like cancer, call for the use of MRI—the gold standard for noninvasive, high-contrast, three-dimensional clinical imaging.
     
    In the present study, the researchers show that they could achieve nanodiamond-enhanced MRI by taking advantage of a phenomenon known as the Overhauser effect to boost the inherently weak magnetic resonance signal of diamond through a process called hyperpolarization, in which nuclei are aligned inside a diamond so they create a signal detectable by an MRI scanner. The conventional approach to hyperpolarization uses solid-state physics techniques at cryogenic temperatures, but the signal boost doesn't last very long and is nearly gone by the time the nanoparticle compound is injected into the body. By combining the Overhauser effect with advances in ultra-low-field MRI coming out of the Martinos Center, the researchers were able to overcome this limitation—thus paving the way for high-contrast in vivo nanodiamond imaging over indefinitely long periods of time.
     
    High-performance ultra-low-field MRI is itself a relatively new technology, first reported in Scientific Reports in 2015 by Rosen and Martinos Center colleagues. "Thanks to innovative engineering, acquisition strategies and signal processing, the technology offers heretofore unattainable speed and resolution in the ultra-low-field MRI regime," said Rosen, director of the Low-Field Imaging Laboratory, an assistant professor of Radiology at Harvard Medical School and the senior author of the current paper. "And importantly, by removing the need for massive, cryogen-cooled superconducting magnets, it opens up a number of new opportunities, including the nanodiamond imaging technique we've just described."
     
    The researchers have noted several possible applications for their new approach to nanodiamond-enhanced MRI. These include the accurate detection of lymph node tumors, which can aid in the treatment of metastatic prostate cancer, and exploring the permeability of the blood-brain barrier, which can play an important role in the management of ischemic stroke. Because it provides a measurable MR signal for periods of over a month, the technique could benefit applications such as monitoring the response to therapy.
     
    Included in treatment monitoring are applications in the burgeoning field of personalized medicine. "The delivery of highly specific drugs is strongly correlated with successful patient outcomes," said Waddington, who was honored with the Journal of Magnetic Resonance Young Scientist Award at the 2016 Experimental NMR Conference in recognition of this work. "However, the response to such drugs often varies significantly on an individual basis. The ability to image and track the delivery of these nanodiamond-drug compounds would, therefore, be greatly advantageous to the development of personalized treatments."
     
    The researchers continue to explore the potential of the technique and are now planning a detailed study of the approach in an animal model, while also investigating the behavior of different nanodiamond-drug complexes and imaging them with the new capability.

    Find more information on the study here.
    Related Searches
    • track
    • patient
    • stroke
    • harvard
    Related Knowledge Center
    • Diagnostics
    Suggested For You
    75-Minute Diagnostic Determines COVID Status 75-Minute Diagnostic Determines COVID Status
    Varex Imaging Welcomes New Finance Chief Varex Imaging Welcomes New Finance Chief
    Smart E-Skin, Robotic Hand Could Gather Vital Diagnostic Data Smart E-Skin, Robotic Hand Could Gather Vital Diagnostic Data
    FDA Clears KA Imaging’s Portable Dual-Energy X-Ray Detector FDA Clears KA Imaging’s Portable Dual-Energy X-Ray Detector
    Turner Imaging Systems, Siemens Healthineers Forge New Business Relationship Agreement Turner Imaging Systems, Siemens Healthineers Forge New Business Relationship Agreement
    Former EOS Imaging CEO Appointed to EDAP TMS Board Former EOS Imaging CEO Appointed to EDAP TMS Board
    FDA OKs B. Braun FDA OKs B. Braun's SpaceStation MRI
    Diagnostic May Bring Faster, Cheaper Cancer Testing to Remote Settings Diagnostic May Bring Faster, Cheaper Cancer Testing to Remote Settings
    Scientists Suggest Device to Make Breast MRI More Effective Scientists Suggest Device to Make Breast MRI More Effective
    Less-Than-One-Second COVID Diagnostic Test Developed Less-Than-One-Second COVID Diagnostic Test Developed
    Canon Medical, Surfacide Partner on Imaging Systems Decontamination Canon Medical, Surfacide Partner on Imaging Systems Decontamination
    Avicenna.AI Avicenna.AI's CINA Head Neurovascular Imaging AI Tool Earns FDA Nod
    Centogene Receives EUA for COVID-19 Molecular Diagnostic Test Centogene Receives EUA for COVID-19 Molecular Diagnostic Test
    FDA Approves Axonics FDA Approves Axonics' r-SNM System for 3T Full-Body MRI Scans
    How Are MPO’s Top 30 Addressing COVID-19? How Are MPO’s Top 30 Addressing COVID-19?

    Related Content

    • Diagnostics
      75-Minute Diagnostic Determines COVID Status

      75-Minute Diagnostic Determines COVID Status

      Abacus Diagnostica is also developing a multiplex assay for COVID, influenza, and RSV.
      Abacus Diagnostica 09.24.20

    • Varex Imaging Welcomes New Finance Chief

      Varex Imaging Welcomes New Finance Chief

      Company's latest CFO has worked for several semiconductor developers.
      Business Wire 09.21.20

    • Diagnostics | Electronics
      Smart E-Skin, Robotic Hand Could Gather Vital Diagnostic Data

      Smart E-Skin, Robotic Hand Could Gather Vital Diagnostic Data

      Relies on easily manufacturable rubber semiconductor.
      University of Houston 09.17.20


    • Diagnostics
      FDA Clears KA Imaging’s Portable Dual-Energy X-Ray Detector

      FDA Clears KA Imaging’s Portable Dual-Energy X-Ray Detector

      With the 510(k) clearance, practitioners can leverage dual-energy at the bed side for the first time.
      KA Imaging 09.08.20

    • Turner Imaging Systems, Siemens Healthineers Forge New Business Relationship Agreement

      Turner Imaging Systems, Siemens Healthineers Forge New Business Relationship Agreement

      Turner's Smart-C Mini C-Arm will be added to Siemens' product portfolio.
      Business Wire 09.08.20


      Breaking News
      • Linear Health Sciences’ Orchid SRV Receives FDA & Health Canada Approval
      • Vivasure Medical Raises $23 Million in Series D Financing Round
      • New Patents Add Value to Know Labs' Bio-RFID Tech
      • Ra Medical Granted Patent for Catheters With Expanded Ablation Area
      • ReCor Medical Presents Data from Two Randomized Trials
      View Breaking News >
      CURRENT ISSUE

      May 2022

      • Cybersecurity Challenges Leave Medical Device Makers Insecure
      • Contract Design for Medtech
      • Diabetes Medical Device Technology Update
      • Medtech Full-Service Outsourcing Q&A 2022

      Cookies help us to provide you with an excellent service. By using our website, you declare yourself in agreement with our use of cookies.
      You can obtain detailed information about the use of cookies on our website by clicking on "More information”.

      • About Us
      • Privacy Policy
      • Terms And Conditions
      • Contact Us

      follow us

      Subscribe
      Nutraceuticals World

      Latest Breaking News From Nutraceuticals World

      Nootropics and Adaptogens Respond to Demand for Mind and Mood Support
      Sabinsa Honors 70th Anniversary of Diplomacy Between India and Japan
      Solvay Invests in Suanfarma’s Vanillin Production
      Coatings World

      Latest Breaking News From Coatings World

      DIC’s Indian Subsidiary Begins Construction of Coating Resins Production Facility
      Celanese Declares Force Majeure on Acetyl Chain and Acetate Tow Products
      CPI Announces New Hybrid Professional Development Program for 2022
      Medical Product Outsourcing

      Latest Breaking News From Medical Product Outsourcing

      Linear Health Sciences’ Orchid SRV Receives FDA & Health Canada Approval
      Vivasure Medical Raises $23 Million in Series D Financing Round
      New Patents Add Value to Know Labs' Bio-RFID Tech
      Contract Pharma

      Latest Breaking News From Contract Pharma

      Evotec SE and Sernova Corp Announce Partnership in the Field of Diabetes
      Emergex COVID-19 Vaccine Candidate Successfully Coated onto Zosano Micro-Needle Patch
      Thabor Therapeutics Appoints Jérémie Mariau as CEO
      Beauty Packaging

      Latest Breaking News From Beauty Packaging

      Aveda is Leaping Bunny Approved by Cruelty Free International
      Smashbox Expands Becca Highlighter Collection
      Bite Beauty Is Closing Later This Year
      Happi

      Latest Breaking News From Happi

      Filipino Cosmetics Company Sunnies Face Enters US Market
      Selig Group Names Adam Sheridan Next President
      Nautica Introduces Oceans Pacific Coast Vegan & Sustainable Fine Fragrance Collection
      Ink World

      Latest Breaking News From Ink World

      Nazdar Ink Technologies to Manufacture VFP Ink Technologies Electronic Inks for US
      Sun Chemical Heads to Flexo and Labels 2022
      PETRONAS Chemicals Group to Acquire Perstorp Group
      Label & Narrow Web

      Latest Breaking News From Label & Narrow Web

      Essentra Packaging invests in Landa Nanographic press
      Nazdar to manufacture VFP electronic ink for US Market
      SunDance moves into flexible packaging with HP Indigo
      Nonwovens Industry

      Latest Breaking News From Nonwovens Industry

      H&V Appoints Vice President and General Counsel
      The Honest Company to Sell Diapers, Wipes at Walmart
      Jim Cree Joins Monadnock Nonwovens
      Orthopedic Design & Technology

      Latest Breaking News From Orthopedic Design & Technology

      Paragon 28 Launches Grappler Suture Anchor System
      Paul Stellato Appointed Chief Accounting Officer at Zimmer Biomet
      DuPuy Synthes’ INHANCE Shoulder System Cleared by FDA for Reverse Total Shoulder Arthroplasty
      Printed Electronics Now

      Latest Breaking News From Printed Electronics Now

      Jabil Strengthens Additive Manufacturing Offerings
      Avery Dennison, Wiliot Partner to Build and Scale the Future of IoT
      HP Delivers Enhanced Platform Capabilities to Accelerate Additive Manufacturing Production at Scale

      Copyright © 2022 Rodman Media. All rights reserved. Use of this constitutes acceptance of our privacy policy The material on this site may not be reproduced, distributed, transmitted, or otherwise used, except with the prior written permission of Rodman Media.

      AD BLOCKER DETECTED

      Our website is made possible by displaying online advertisements to our visitors.
      Please consider supporting us by disabling your ad blocker.


      FREE SUBSCRIPTION Already a subscriber? Login