U.S. Patent Granted to ENvue Medical for Real-Time Imaging Overlay

NanoVibronix Inc. subsidiary ENvue Medical Holdings LLC has been awarded a U.S. patent protecting its proprietary method of overlaying electromagnetic (EM) navigation data directly onto real-time medical imaging modalities such as X-ray, computed tomography (CT), ultrasound, and MRI.

Titled, “Insertion Device Positioning Guidance System and Method,” U.S. Patent No. 12,402,953 B2 fortifies ENvue’s IP portfolio and protects key technology that helps clinicians visualize the live path of a feeding tube or catheter directly on medical images. The real-time overlay aims to increase procedural confidence, reduce misplacement risk, and create hospital workflow efficiencies.

“Navigation alone is not new,” NanoVibronix CEO Doron Besser, M.D., said. “What sets ENvue apart is our ability to integrate navigation with imaging in real time, a capability now protected by this patent. This differentiation strengthens our leadership in the feeding tube placement market, where precision and workflow efficiency are critical. We believe it also provides a strong foundation for expansion into vascular navigation, broadening our addressable market and long-term potential. With this addition to our global patent portfolio, we believe ENvue is well-positioned to lead in both current and future clinical applications.”

NanoVibronix Inc. is a medical technology company advancing both non-invasive and minimally invasive solutions across clinical and home care settings. Headquartered in Tyler, Texas, with research and development in Nesher, Israel, the company focuses on two distinct technology platforms. The first is acoustic-based therapeutic technologies—including PainShield and UroShield—which utilize proprietary low-intensity surface acoustic wave (SAW) technology. These devices are intended for use in the home or care settings and are designed to treat pain, reduce bacterial colonization, and disrupt biofilms.

The second platform is the ENvue Navigation Platform, developed and operated by ENvue Medical, a NanoVibronix subsidiary with offices in Arlington Heights, Ill., and Tel Aviv, Israel. The platform is a minimally invasive electromagnetic navigation system intended to assist clinicians in placing feeding tubes into the gastrointestinal tract. The solution is 510(k) cleared by the U.S. Food and Drug Administration for adult use; ENvue provides real-time bedside visualization of tube movement and supports informed decision-making during the placement procedure. Future platform expansion may include pediatric and vascular access applications.

NanoVibronix strives to advance standards in non-invasive therapy and minimally invasive navigation, with a commitment to patient safety, clinical usability, and technology innovation across numerous healthcare environments.