Baxter Launches First 3-in-1 Set for Use in Continuous Renal Replacement Therapy, Sepsis Management

Baxter International Inc., a global developer of acute care therapies, has launched a new indication for the company’s oXiris set, which can now be used to help remove excessive levels of cytokines, endotoxin and other inflammatory mediators from a patient’s blood. This makes oXiris the first blood purification set that can be used in continuous renal replacement therapy (CRRT) and sepsis management protocols. 

Previously, the oXiris set was only indicated for CRRT, which is a type of extracorporeal (outside the body) blood purification (EBP) used with Baxter’s Prismaflex system to manage patients with acute kidney injury (AKI).
 
The use of EBP to remove cytokines and endotoxin from the blood represents a promising approach to treat conditions where excessive levels of those inflammatory mediators are seen in the patient’s blood. Elevated levels of inflammatory mediators cytokines and endotoxin are frequently seen in patients with sepsis, a serious medical condition affecting up to 40 percent of critically ill patients in the intensive care unit. ^1-7 For that reason, EBP is being studied for its potential to help address sepsis, a condition for which new therapeutic approaches have not shown to be effective.⁸ However, confirmation of such an association is challenging, in part due to the population of critically ill patients with AKI and/or sepsis, and because these patients often require multiple therapeutic interventions⁹—a characteristic that complicates assessment of individual treatment outcomes.
 
“Extracorporeal blood purification for sepsis is an area where we do not have a lot of robust published research and where there is little scientific consensus, so it’s difficult for healthcare providers to determine the most effective way to treat their patients,” said Thomas Rimmelé, M.D., Ph.D., chairman of the Anesthesia and Resuscitation Service Department at Hôpital Edouard Herriot in Lyon, France. “What I find most interesting about the oXiris set is that it is now able to filter the blood of cytokines and endotoxin while simultaneously treating acute kidney injury.”

Baxter received CE mark and regulatory approval for the label expansion in more than 30 countries in Europe and certain countries in the Middle East and Africa. The new indication is also planned for Hong Kong. Baxter currently plans to file for the expanded indication in additional countries in 2018 and beyond. The oXiris set is not currently approved in the United States.

“Baxter is leading the way in advancing treatments for the most critically ill patients in a hospital and finding innovative solutions where there are few effective options available today,” said Reaz Rasul, general manager of Acute Therapies at Baxter. “This launch illustrates our commitment to providing healthcare providers with new applications for products used on our Prismaflex system to drive better care.”
 
A leader in multi-organ support therapy options, Baxter has been advancing new technologies and treatment for critically ill patients around the world. Baxter’s Prismaflex system offers clinicians the flexibility to meet patients’ diverse needs and powers its portfolio of products to deliver a complete range of extracorporeal (outside the body) blood purification (EBP) therapies to help manage patients with AKI, acute respiratory distress syndrome, autoimmune diseases and/or sepsis. Prismax, Baxter’s next generation EBP system, is currently expected to launch commercially in select countries in 2018.
 
Baxter provides a broad portfolio of essential renal and hospital products, including home, acute and in-center dialysis; sterile IV solutions; infusion systems and devices; parenteral nutrition; surgery products and anesthetics; and pharmacy automation, software and services. The company’s global footprint and the critical nature of its products and services play a key role in expanding access to healthcare in emerging and developed countries. Baxter, Prismaflex and oXiris are trademarks of Baxter International Inc. or its subsidiaries.

References
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