• Login
    • Join
  • FOLLOW:
  • Subscribe Free
    • Magazine
    • eNewsletter
    Checkout
    • Magazine
    • News
    • Opinions
    • Top 30
    • Research
    • Supply Chain
    • Device Sectors
    • Directory
    • Events
    • Resources
    • Microsites
    • More
  • Magazine
  • News
  • Opinions
  • Top 30
  • Research
  • Supply Chain
  • Device Sectors
  • Directory
  • Events
  • Resources
  • Microsites
  • Current / Back Issues
    Features
    Editorial
    Digital Edition
    eNewsletter Archive
    Our Team
    Editorial Guidelines
    Reprints
    Subscribe Now
    Advertise Now
    Top Features
    MPO's 2023 Medical Device Industry Year in Review

    The Beat Goes On in the Cardiovascular Device Market

    Medical Manufacturers Gain Support from 3D Printing

    The Intelligent Tools Medical Device Manufacturers Already Own

    MPO's 2023 Medtech Supply Chain Survey
    OEM News
    Supplier News
    Service / Press Releases
    Online Exclusives
    Press Releases
    People in the News
    Product & Service Releases
    Supplier News
    Medtech Makers
    Technical Features
    International News
    Videos
    Product & Service Releases
    Live From Shows
    Regulatory
    Financial/Business
    Top News
    MPO's Most-Read Stories This Week—Dec. 9

    Babson Diagnostics’ BetterWay Achieves Regulatory Milestone

    WhiteSwell Successfully Treats Acute Decompensated Heart Failure in Study

    Everly Health Releases At-Home Collection Kidney Health Test

    Kenco Adds Two to its Life Sciences Division Team
    From the Editor
    Blogs
    Guest Opinions
    Top Opinions
    MPO's 2023 Medical Device Industry Year in Review

    The Beat Goes On in the Cardiovascular Device Market

    Medical Manufacturers Gain Support from 3D Printing

    The Intelligent Tools Medical Device Manufacturers Already Own

    MPO's 2023 Medtech Supply Chain Survey
    Top 30 Medical Device Companies
    Market Data
    White Papers
    Top Research
    A Peek Into the 2028 MPO Summit

    Retail Healthcare Disruptors and Medical Devices

    Six Developments Your Talent Strategy Should Prepare for in 2024

    The Power and Paradox of Never

    Navigating the Q-Sub Program: How Experienced Lab Partners Can Help Streamline Regulatory Submission
    3D/Additive Manufacturing
    Contract Manufacturing
    Electronics
    Machining & Laser Processing
    Materials
    Molding
    Packaging & Sterilization
    R&D & Design
    Software & IT
    Testing
    Tubing & Extrusion
    Cardiovascular
    Diagnostics
    Digital Health
    Neurological
    Patient Monitoring
    Surgical
    Orthopedics
    All Companies
    Categories
    Company Capabilities
    Add New Company
    Outsourcing Directory
    Johari Digital Healthcare Ltd.

    BMP Medical

    Medbio LLC

    Providence Enterprise USA Inc.

    Halkey-Roberts Corporation
    MPO Summit
    Industry Events
    Webinars
    Live From Show Event
    Industry Associations
    Videos
    Career Central
    eBook
    Slideshows
    Top Resources
    Telemedicine for Neurology: 5 Benefits of Remote Management

    Machining 101: A Review of Machining Components with a Five-Axis System

    MedTech 2024: Top 5 Trends Shaping a Dynamic Industry

    Early Warning: A Q&A with Abbott's CMO of Heart Failure

    2023 in Review: Medtech's Mega-M&A Is MIA
    Companies
    News Releases
    Product Releases
    Press Releases
    Product Spec Sheets
    Service Releases
    Case Studies
    White Papers
    Brochures
    Videos
    Outsourcing Directory
    Johari Digital Healthcare Ltd.

    BMP Medical

    Medbio LLC

    Providence Enterprise USA Inc.

    Halkey-Roberts Corporation
    • Magazine
      • Current/Back Issues
      • Features
      • Editorial
      • Columns
      • Digital Editions
      • Subscribe Now
      • Advertise Now
    • News
    • Directory
      • All Companies
      • ALL CATEGORIES
      • Industry Associations
      • Company Capabilities
      • Add Your Company
    • Supply Chain
      • 3D/Additive Manufacturing
      • Contract Manufacturing
      • Electronics
      • Machining & Laser Processing
      • Materials
      • Molding
      • Packaging & Sterilization
      • R&D & Design
      • Software & IT
      • Testing
      • Tubing & Extrusion
    • Device Sectors
      • Cardiovascular
      • Diagnostics
      • Digital Health
      • Neurological
      • Patient Monitoring
      • Surgical
      • Orthopedics
    • Top 30 Company Report
    • Expert Insights
    • Slideshows
    • Videos
    • eBook
    • Resources
    • Podcasts
    • Infographics
    • Whitepapers
    • Research
      • White Papers
      • Case Studies
      • Product Spec Sheets
      • Market Data
    • MPO Summit
    • Events
      • Industry Events
      • Live From Show Events
      • Webinars
    • Microsite
      • Companies
      • Product Releases
      • Product Spec Sheets
      • Services
      • White Papers / Tech Papers
      • Press Releases
      • Videos
      • Literature / Brochures
      • Case Studies
    • About Us
      • About Us
      • Contact Us
      • Advertise with Us
      • eNewsletter Archive
      • Privacy Policy
      • Terms of Use
    Breaking News

    Early Catheter Ablation of VT Outperforms Conventional Medical Therapy

    First randomized trial of its kind to enroll patients with nonischemic cardiomyopathy.

    Heart Rhythm Society08.05.21
    Results from an international clinical trial show a significant reduction in risk of ventricular tachycardia (VT) recurrence, cardiovascular hospitalization, and death when catheter ablation is used as an early first-line treatment for patients with structural heart disease. Led by study coordinating center, the University of Chicago, The PAUSE-SCD trial is the first VT ablation trial to include patients with nonischemic cardiomyopathy and to be conducted across Asia. Findings of this landmark trial were presented as late-breaking science during Heart Rhythm 2021.
     
    Sudden cardiac death is one of the leading causes of death around the world,1 occurring when blood flow to the brain is restricted due to a malfunctioning electrical system in the heart and is not treated within minutes. Patients with VT—a heart rhythm disorder that involves a dangerously fast heartbeat—and other structural heart diseases are at an increased risk of SCA.2 As the study was conducted in Asia, the largest populous continent at risk of SCD, VT patients with nonischemic cardiomyopathy were included due to higher prevalence relative to ischemic cardiomyopathy. Nonischemic cardiomyopathy is a condition with decreased heart muscle function related to causes other than a prior heart attacks or coronary artery blockage.
     
    The international, multi-center, randomized controlled trial was conducted in 11 sites across China, Japan, Korea, and Taiwan in collaboration with University of Chicago Medicine, who served as the study coordinating center. A total of 121 patients with structural heart disease or monomorphic VT indicated for implantable defibrillator (ICD) therapy were enrolled. Patients were randomized one to one to either ablation within 90 days of ICD implantation or medical therapy. Patients who refused ICD therapy were followed in a prospective registry after stand-alone ablation treatment. The primary outcome included a triple composite of VT recurrence, cardiovascular hospitalization, and death. The study was conducted over a six-year period with a median patient follow-up of 31 months.
     
    Key findings of the trial reveal catheter ablation as a first-line treatment within 90 days of ICD therapy reduced the relative risk of VT recurrence, cardiovascular hospitalization, and death by 42 percent across varied etiologies of structural heart disease. Over the median follow-up period, the primary outcome occurred in 45 percent of patients who underwent ablation and 59 percent in those managed with conventional medical therapy (hazard ratio 0.58, 95 percent confidence interval, 0.35-0.96; P=0.036). Ablation was performed a median of two days prior to ICD implantation (IQR five days prior-14 days after). There were 8 percent procedural-related complications in the ablation group.
     
    “This is only one of three clinical trials to provide an in-depth look at catheter ablation as a preventive measure for patients at risk of life-threatening sudden cardiac events,” said Roderick Tung, M.D., FHRS, University of Chicago and lead author. “Ablation has historically been viewed as a palliative, last-resort strategy and bringing it upfront as concurrent therapy with ICD implantation is a potentially meaningful paradigm shift. It is also the first to include patients with VT without prior myocardial infarction as well as the first to include more contemporary procedural strategies, such as high-resolution mapping and epicardial approaches. We hope that these results will influence future guidelines that are trending toward earlier use of catheter ablation over medical therapy in the course of patient treatment.”
     
    Additionally, study results showed the ablation registry that enrolled patients who did not receive an ICD had higher freedom from recurrent VT compared to medical therapy with no significant differences in mortality. The authors express that this opens the door for scientific questioning as to whether ablation without defibrillator therapy may be acceptable in highly selected patients. Further, they note that defibrillator therapy is not affordable for many around the world, reinforcing the importance of a future studies that could potentially randomize patients with nonischemic cardiomyopathy, a group that has not shown consistent survival advantage with ICD implantation, to stand-alone ablation therapy.

    References
    1 Adabag AS, Luepker RV, Roger VL, Gersh BJ. Sudden cardiac death: epidemiology and risk factors. Nat Rev Cardiol 2010;7:216–25.
    2 Koplan, B. A., & Stevenson, W. G. (2009). Ventricular tachycardia and sudden cardiac death. Mayo Clinic proceedings, 84(3), 289–297. https://doi.org/10.1016/S0025-6196(11)61149-X
    Related Searches
    • Cardiovascular
    Related Knowledge Center
    • Cardiovascular
    Suggested For You
    Junkosha USA Inc. Junkosha USA Inc.
    Heraeus Medevio Heraeus Medevio
    sfm medical devices GmbH sfm medical devices GmbH
    JK Medirise-Disposable Medical Device Company JK Medirise-Disposable Medical Device Company
    MEDICAL & BIOTECH MANUFACTURING MEDICAL & BIOTECH MANUFACTURING
    Northeast Biomedical Inc. Northeast Biomedical Inc.
    BMP Medical - Delivering Custom Plastics Manufactured Solutions BMP Medical - Delivering Custom Plastics Manufactured Solutions
    High Tech Turning Co. Inc. High Tech Turning Co. Inc.
    Breakthrough Device Designation Granted for New Neuromodulation Platform Breakthrough Device Designation Granted for New Neuromodulation Platform
    Hyperfine Names Paykel, Teisseyre to Executive Leadership Roles Hyperfine Names Paykel, Teisseyre to Executive Leadership Roles
    Accu-Tube Appoints Matthew Haddle as CEO Accu-Tube Appoints Matthew Haddle as CEO
    First CellFX Procedure Performed in Canada First CellFX Procedure Performed in Canada
    Turner Imaging Systems Announces International Expansion Turner Imaging Systems Announces International Expansion
    Heraeus Acquires Mo-Sci Corporation, ETS Technology Holdings Heraeus Acquires Mo-Sci Corporation, ETS Technology Holdings
    MedTech Innovator Names the Finalists for the Title of MedTech Innovator 2021 MedTech Innovator Names the Finalists for the Title of MedTech Innovator 2021

    Related Buyers Guide Companies

    • Junkosha USA Inc.

      Junkosha USA Inc.

      ...
      Andy Parker, Director 11.29.23

    • Heraeus Medevio

      Heraeus Medevio

      Heraeus is a globally active precious metals and technology Group with firm roots in Germany, headquartered in Hanau near Frankfurt.
      Sara Kruper, Global Marketing Manager 10.17.23

    • sfm medical devices GmbH

      ...
      Albert Busch, Head of Marketing 10.17.23


    • JK Medirise-Disposable Medical Device Company

      ...
      Ketan Munjani, Marketing Manager 09.28.23

    • MEDICAL & BIOTECH MANUFACTURING

      ISO 13485:2016 • FDA Registered

    Loading, Please Wait..

    Breaking News
    • MPO's Most-Read Stories This Week—Dec. 9
    • Babson Diagnostics’ BetterWay Achieves Regulatory Milestone
    • WhiteSwell Successfully Treats Acute Decompensated Heart Failure in Study
    • Everly Health Releases At-Home Collection Kidney Health Test
    • Kenco Adds Two to its Life Sciences Division Team
    View Breaking News >
    CURRENT ISSUE

    November 2023

    • MPO's 2023 Medical Device Industry Year in Review
    • The Beat Goes On in the Cardiovascular Device Market
    • Medical Manufacturers Gain Support from 3D Printing
    • The Intelligent Tools Medical Device Manufacturers Already Own
    • View More >

    Cookies help us to provide you with an excellent service. By using our website, you declare yourself in agreement with our use of cookies.
    You can obtain detailed information about the use of cookies on our website by clicking on "More information”.

    • About Us
    • Privacy Policy
    • Terms And Conditions
    • Contact Us

    follow us

    Subscribe
    Nutraceuticals World

    Latest Breaking News From Nutraceuticals World

    Women in Nutraceuticals Hires Executive Director Rebecca Takemoto
    FDA Issues Interim Response to Nammex’s Mushroom Labeling Petition
    MSM Linked to Improvements in Knee Pain
    Coatings World

    Latest Breaking News From Coatings World

    Weekly Recap: PPG, PPG Asian Paints, AkzoNobel Top This Week’s Stories
    Orion S.A. Has Four Carbon Black Plants Awarded ISCC PLUS
    Peninsula Polymers Acquires New Distribution Center in Indiana
    Medical Product Outsourcing

    Latest Breaking News From Medical Product Outsourcing

    MPO's Most-Read Stories This Week—Dec. 9
    Babson Diagnostics’ BetterWay Achieves Regulatory Milestone
    WhiteSwell Successfully Treats Acute Decompensated Heart Failure in Study
    Contract Pharma

    Latest Breaking News From Contract Pharma

    FDA Approves Bio-Thera's Biosimilar Referencing Roche’s Avastin
    Full-Life Technologies to Build GMP Radiopharmaceuticals Mfg. Facility
    Innovent Biologics, Synaffix Expand ADC Licensing Deal
    Beauty Packaging

    Latest Breaking News From Beauty Packaging

    COSRX’s Latest TikTok Campaign Accumulates 3.2B Views on TikTok
    Christian Louboutin Taps Morgane Martini as Global Makeup Artist
    Shiseido Forms New Venture Fund
    Happi

    Latest Breaking News From Happi

    Christian Louboutin Names Morgane Martini Global Makeup Artist
    Estée Lauder Lead Scientist Dr. Nadine Pernodet To Lecture At SCC Science Meeting
    Topical Testosterone Formulation for Chest Hair Growth
    Ink World

    Latest Breaking News From Ink World

    Weekly Recap: Siegwerk, DIC, and Müller Martini Top This Week’s Stories
    Orion S.A. Now Has Four Carbon Black Plants Awarded ISCC PLUS
    BASF Commits to Scope 3.1 Emissions Targets
    Label & Narrow Web

    Latest Breaking News From Label & Narrow Web

    Analyzing the Russian label market, Carter boosts brands and more
    FLAG’s December Lunch & Learn to feature Omet
    UPM Raflatac releases neuromarketing study findings
    Nonwovens Industry

    Latest Breaking News From Nonwovens Industry

    Ginni Strikes Deal to Sell Spinning, Knitting Operations
    Campen Machinery Announces Patent Pending Status for Airlaid Trays
    Veocel Partners with Beauty and Feminine Care Brands in Asia Pacific
    Orthopedic Design & Technology

    Latest Breaking News From Orthopedic Design & Technology

    ODT's Most-Read Stories This Week—Dec. 9
    Fujitsu, iSurgery Launch Bone Health Promotion Project in Japan
    Wenzel Spine Hires Dr. Robert Gordon as Executive Chairman
    Printed Electronics Now

    Latest Breaking News From Printed Electronics Now

    Weekly Recap: Schreiner MediPharm, GIANCE and PragmatIC Top This Week’s Stories
    Intel CEO Pat Gelsinger to Cover AI During CES 2024 Keynote
    Ciena Invests in US Manufacturing with Flex

    Copyright © 2023 Rodman Media. All rights reserved. Use of this constitutes acceptance of our privacy policy The material on this site may not be reproduced, distributed, transmitted, or otherwise used, except with the prior written permission of Rodman Media.

    AD BLOCKER DETECTED

    Our website is made possible by displaying online advertisements to our visitors.
    Please consider supporting us by disabling your ad blocker.


    FREE SUBSCRIPTION Already a subscriber? Login