• Login
    • Join
  • FOLLOW:
  • Subscribe Free
    • Magazine
    • eNewsletter
    Checkout
    • Magazine
    • News
    • Opinions
    • Top 30
    • Research
    • Supply Chain
    • Device Sectors
    • Directory
    • Events
    • Resources
    • Microsites
    • More
  • Magazine
  • News
  • Opinions
  • Top 30
  • Research
  • Supply Chain
  • Device Sectors
  • Directory
  • Events
  • Resources
  • Microsites
  • Current / Back Issues
    Features
    Editorial
    Digital Edition
    eNewsletter Archive
    Our Team
    Editorial Guidelines
    Reprints
    Subscribe Now
    Advertise Now
    Top Features
    Deep (Brain) Thoughts with Medtronic's Neuromodulation President

    Grab and Go: Examining the Thrombectomy Device Market

    Fine Print: A Discourse on Additive Manufacturing

    MPO's 2022 Medtech Industry Year in Review

    Micro Molding for Medtech Is Miniature Magic
    OEM News
    Supplier News
    Service / Press Releases
    Online Exclusives
    Press Releases
    People in the News
    Product & Service Releases
    Supplier News
    Medtech Makers
    Technical Features
    International News
    Videos
    Product & Service Releases
    Live From Shows
    Regulatory
    Financial/Business
    Top News
    The Producto Group Appoints Mark C. Rauenzahn as Chief Executive Officer

    Coloplast Launches New Catheter in the U.S.

    Josh Ghaim and Sachin Jain Join Cue Health Board of Directors

    NAMSA Relaunches Medtech Outsourcing Solution

    Rollomatic Inc. Welcomes Joe Kane as CEO
    From the Editor
    Blogs
    Guest Opinions
    Top Opinions
    Deep (Brain) Thoughts with Medtronic's Neuromodulation President

    Grab and Go: Examining the Thrombectomy Device Market

    Fine Print: A Discourse on Additive Manufacturing

    MPO's 2022 Medtech Industry Year in Review

    Micro Molding for Medtech Is Miniature Magic
    Top 30 Medical Device Companies
    Market Data
    White Papers
    Top Research
    Reflections on 2022 and What’s Ahead for Medtech: MPO Sounding Board

    3 Ways to Prepare for ISO 13485/Part 820 Harmonization

    A New Home for Theranos' Elizabeth Holmes?

    Health Cost Drivers for Large Employers

    Braving Change: Facing Fears in the Midst of Major Transitions
    3D/Additive Manufacturing
    Contract Manufacturing
    Electronics
    Machining & Laser Processing
    Materials
    Molding
    Packaging & Sterilization
    R&D & Design
    Software & IT
    Testing
    Tubing & Extrusion
    Cardiovascular
    Diagnostics
    Digital Health
    Neurological
    Patient Monitoring
    Surgical
    Orthopedics
    All Companies
    Categories
    Company Capabilities
    Add New Company
    Outsourcing Directory
    Medbio LLC

    Forefront Medical Technology

    Arthur G. Russell Co. Inc., The

    LEMO USA Inc.

    JBC Technologies
    MPO Summit
    Industry Events
    Webinars
    Live From Show Event
    Industry Associations
    Videos
    Career Central
    eBook
    Slideshows
    Top Resources
    How Artificial Intelligence Can Combat Key Issues Impacting Healthcare

    Why Advanced Sensors Are Crucial Within Medical Pumps

    How Artificial Intelligence Could Help Prevent 80% of Chronic Diseases

    4 Ways to Use Injection Molding in Medical Device Manufacturing

    Telemedicine and Connectivity to Drive Material Innovation in the Near Future
    Companies
    News Releases
    Product Releases
    Press Releases
    Product Spec Sheets
    Service Releases
    Case Studies
    White Papers
    Brochures
    Videos
    Outsourcing Directory
    Medbio LLC

    Forefront Medical Technology

    Arthur G. Russell Co. Inc., The

    LEMO USA Inc.

    JBC Technologies
    • Magazine
      • Current/Back Issues
      • Features
      • Editorial
      • Columns
      • Digital Editions
      • Subscribe Now
      • Advertise Now
    • News
    • Directory
      • All Companies
      • ALL CATEGORIES
      • Industry Associations
      • Company Capabilities
      • Add Your Company
    • Supply Chain
      • 3D/Additive Manufacturing
      • Contract Manufacturing
      • Electronics
      • Machining & Laser Processing
      • Materials
      • Molding
      • Packaging & Sterilization
      • R&D & Design
      • Software & IT
      • Testing
      • Tubing & Extrusion
    • Device Sectors
      • Cardiovascular
      • Diagnostics
      • Digital Health
      • Neurological
      • Patient Monitoring
      • Surgical
      • Orthopedics
    • Top 30 Company Report
    • Expert Insights
    • Slideshows
    • Videos
    • eBook
    • Resources
    • Podcasts
    • Infographics
    • Whitepapers
    • Research
      • White Papers
      • Case Studies
      • Product Spec Sheets
      • Market Data
    • MPO Summit
    • Events
      • Industry Events
      • Live From Show Events
      • Webinars
    • Microsite
      • Companies
      • Product Releases
      • Product Spec Sheets
      • Services
      • White Papers / Tech Papers
      • Press Releases
      • Videos
      • Literature / Brochures
      • Case Studies
    • About Us
      • About Us
      • Contact Us
      • Advertise with Us
      • eNewsletter Archive
      • Privacy Policy
      • Terms of Use
    Breaking News

    Sandia's SpinDx Enables Mobile Testing for Viruses, Bacteria, and Active toxins

    SpinDx has been licensed by industry partners for uses as diverse as male fertility testing and water supply safety monitoring.

    Sandia
    Sandia National Laboratories chemist Chung-Yan Koh, left, and former Sandia bioengineer Chris Phaneuf hold the newly updated SpinDx diagnostic device. Image courtesy of Jules Bernstein.
    Related CONTENT
    • Biomedical Engineers Grow 3D Bioprinted Blood Vessel
    • FDA OKs Baxter's AK 98 Hemodialysis Machine
    • Colonoscopy-Like Bacteria Grabber Could Uncover Health Secrets
    • Terumo's Mirasol Shows Efficacy Against Virus Causing COVID-19 in Plasma, Platelets
    • BD Gains Second EUA for CE-Marked Molecular Diagnostic Test
    Sandia National Laboratories01.10.19
    You’re sweating and feverish and have no idea why. Fortunately, Sandia National Laboratories scientists have a device that can pinpoint what’s wrong in less than an hour.
     
    Unlike most medical diagnostic devices which can perform only one type of test—either protein or nucleic acid tests—Sandia’s SpinDx can now perform both. This allows it to identify nearly any cause of illness, including viruses, bacteria, toxins or immune system markers of chemical agent exposure.
     
    The new addition of a heating element allows SpinDx to do the nucleic acid tests, which search for genetic codes found in any kind of virus, parasite or bacteria. The technology can also detect toxin proteins at the same time and determine whether they are active or not—a critical distinction for correctly tailoring the level of medical response.
     
    The device’s portability, affordability, rapidity, and reliability are critical for addressing infectious disease outbreaks in places most affected by them and least able to afford a laboratory with traditional instruments. In developing nations, diarrhea is the second leading cause of death in children under age 5, according to World Health Organization reports. These deaths are largely preventable when the causes are detected, and treatment is administered early.
     
    Helping save these lives is why Sandia’s scientists decided to test the new SpinDx capabilities on potential causes of diarrheal disease. Sandia’s research shows SpinDx successfully detects both diarrhea-causing toxins and bacteria in stool samples. Results of these tests were recently published in the journal Biosensors and Bioelectronics.
     
    Spinning Toward Solutions
    SpinDx looks a bit like a DVD player inside a weather-resistant plastic case. It features a disposable disc that distributes drops of raw, unprocessed biological samples into different channels that function, according to Sandia chemist Chung-Yan Koh, like “dozens of tiny test tubes.”
     
    This automatic distribution step is a great time saver. Chris Phaneuf, a former Sandia bioengineer explains, “instead of having to drop processed samples one by one into dozens of tiny chambers, you can load one raw sample into a single, central port that evenly distributes your sample into every channel.” Phaneuf is now senior fluidics engineer at Illumina in San Diego, where he develops technologies for genetic research.
     
    When the disc spins, the samples interact with test reagents inside the channels, and, as Phaneuf puts it, “if there’s a match, they’ll attach.” In other words, if there is a chemical interaction between the sample and reagent, a red laser causes the tip of the channel to glow, signaling an infectious agent to a software interface that displays the result.
     
    Previously SpinDx performed only protein tests, which look for both pathogen-specific proteins and antibodies. Antibodies are proteins manufactured by immune systems in response to infections. When viruses later disappear from the blood, the antibodies that flushed them are still detectable. Protein tests also can identify lethal toxins like botulinum neurotoxin, a teaspoon of which has the potential to kill around 100 million people, according to Phaneuf.
     
    Shining a LAMP on Symptoms
    Thanks to its new heating element and ability to do a new assay, SpinDx can conduct nucleic acid tests able to identify the virus or bacteria responsible for causing symptoms like diarrhea. “It’s much quicker to detect the causative pathogen in a sample than to wait for a body to produce antibodies to an infection,” Phaneuf said. “Being able to do both kinds of tests paints the most complete picture of what’s in a person’s system.”
     
    Conventional viral testing (via polymerase chain reaction or PCR) requires heating and cooling a biological sample many times to multiply any viral DNA or RNA to detectable levels. Phaneuf and Koh implemented a new Sandia-developed assay and detection scheme in the SpinDx update, which uses chemistry that requires the sample be heated only once.
     
    In other systems, the loop-mediated isothermal amplification (LAMP) method of heating a sample takes place atop a small heating block that creates a single, uniform temperature inside a device. SpinDx uses a tiny infrared heat emitter that hovers at the top of the device, targeting the part of the spinning disc performing the test and nowhere else.
     
    Being able to control the heat flow allows for different temperature zones inside SpinDx, enabling the simultaneous nucleic acid and protein tests. Nucleic acid tests require a temperature that would ordinarily destroy a sample’s proteins.
     
    A Diagnostic Revolution
    SpinDx has been licensed by industry partners for uses as diverse as male fertility testing and water supply safety monitoring. With its new capabilities, SpinDx has the potential to improve diagnostic problems in settings around the world, and not just for humans.
     
    Phaneuf described a highly contagious virus ravaging goats and sheep in parts of the world where those animals are central to peoples’ livelihoods. These communities often don’t have access to a laboratory, but this tool could quickly diagnose their animals and allow for proper treatment.
     
    Sandia is also currently using the technology for research into applications as diverse as bioenergy and chemical warfare detection. In the former case, scientists are using SpinDx to search for predators that could cause the crash of algae being cultivated for biofuels and renewable chemicals.
     
    In the latter case, Koh is testing soldiers for exposure to chemical warfare agents. The Defense Threat Reduction Agency-funded project will use SpinDx to search for biomarkers of exposure. Temperature control in this research is essential because it makes the test more precise, Koh said.
     
    In addition, there is a very short window for treatment should a soldier be exposed to a chemical agent. The speed with which SpinDx can deliver results could help ensure the treatment is administered in time for it to be effective.
     
    The ability to accurately conduct all these tests at the same time in one portable device and read the results in an hour or less sets SpinDx apart from other available systems. Traditionally, these results have required a well-equipped laboratory staffed with experienced technicians.
     
    Koh and Phaneuf say they’d like to see batteries and solar panels added to SpinDx, making it deployable almost anywhere. It could even one day help a doctor quickly determine whether your symptoms are from the flu, your food or something else entirely.
    Related Searches
    • blood
    • rna
    • monitoring
    • Software
    Related Knowledge Center
    • Diagnostics
    Suggested For You
    Biomedical Engineers Grow 3D Bioprinted Blood Vessel Biomedical Engineers Grow 3D Bioprinted Blood Vessel
    FDA OKs Baxter FDA OKs Baxter's AK 98 Hemodialysis Machine
    Colonoscopy-Like Bacteria Grabber Could Uncover Health Secrets Colonoscopy-Like Bacteria Grabber Could Uncover Health Secrets
    Terumo Terumo's Mirasol Shows Efficacy Against Virus Causing COVID-19 in Plasma, Platelets
    BD Gains Second EUA for CE-Marked Molecular Diagnostic Test BD Gains Second EUA for CE-Marked Molecular Diagnostic Test
    Battelle Develops Decontamination System for Medical Protective Equipment Battelle Develops Decontamination System for Medical Protective Equipment
    Advanced Sterilization Products Extends the Lifespan of N95 Masks Advanced Sterilization Products Extends the Lifespan of N95 Masks
    New Test Can Diagnose COVID-19 in as Little as Five Minutes New Test Can Diagnose COVID-19 in as Little as Five Minutes
    Fully Automated BD Phoenix CPO Detect Test Receives FDA Clearance Fully Automated BD Phoenix CPO Detect Test Receives FDA Clearance
    Microneedle Device Could Provide Quicker Diagnoses of Major Illnesses Microneedle Device Could Provide Quicker Diagnoses of Major Illnesses
    Imminent Release of the World Imminent Release of the World's First Saliva Test for Malaria
    MedTech Innovator Opens Applications for 2019 Competition MedTech Innovator Opens Applications for 2019 Competition
    The Regulatory Outlook for 2019 The Regulatory Outlook for 2019
    Boston Scientific Acquires U.K.-Based BTG for $4.2B Boston Scientific Acquires U.K.-Based BTG for $4.2B
    New Software for More Efficient Minimally Invasive Surgery Planning New Software for More Efficient Minimally Invasive Surgery Planning

    Related Breaking News

    • Cardiovascular
      Biomedical Engineers Grow 3D Bioprinted Blood Vessel

      Biomedical Engineers Grow 3D Bioprinted Blood Vessel

      Paves the way for possible cardiovascular drug advancements with better precision.
      Texas A&M Engineering 08.19.21

    • Chronic Disease
      FDA OKs Baxter

      FDA OKs Baxter's AK 98 Hemodialysis Machine

      Can be used alongside Theranova, Baxter’s novel dialysis membrane.
      Sam Brusco, Associate Editor 03.15.21

    • Diagnostics | Patient Monitoring
      Colonoscopy-Like Bacteria Grabber Could Uncover Health Secrets

      Colonoscopy-Like Bacteria Grabber Could Uncover Health Secrets

      Swallowed tool acts like colonoscopy, but instead of looking at the colon with a camera, it takes bacterial samples.
      Purdue University


    • Terumo

      Terumo's Mirasol Shows Efficacy Against Virus Causing COVID-19 in Plasma, Platelets

      The pathogen reduction system is designed to add an extra layer of safety to the blood supply.
      Terumo BCT 04.20.20

    • Diagnostics
      BD Gains Second EUA for CE-Marked Molecular Diagnostic Test

      BD Gains Second EUA for CE-Marked Molecular Diagnostic Test

      New test uses BD Max System to augment supply from existing collaborations; test results in under three hours.
      BD 04.13.20

    Loading, Please Wait..

    Trending
    • The Future Of Biomedical Engineering Advancements
    • Cirtec Medical Corporation Acquires Precision Components Business From QMD
    • FDA Clears LiveMetric's Wearable Blood Pressure Monitoring Tech
    • Coloplast Launches New Catheter In The U.S.
    • A New Approach To Post-Market Surveillance
    Breaking News
    • The Producto Group Appoints Mark C. Rauenzahn as Chief Executive Officer
    • Coloplast Launches New Catheter in the U.S.
    • Josh Ghaim and Sachin Jain Join Cue Health Board of Directors
    • NAMSA Relaunches Medtech Outsourcing Solution
    • Rollomatic Inc. Welcomes Joe Kane as CEO
    View Breaking News >
    CURRENT ISSUE

    November 2022

    • MPO's 2022 Year in Review
    • Fine Print: A Discourse on Additive Manufacturing
    • Grab and Go: Examining the Thrombectomy Device Market
    • View More >

    Cookies help us to provide you with an excellent service. By using our website, you declare yourself in agreement with our use of cookies.
    You can obtain detailed information about the use of cookies on our website by clicking on "More information”.

    • About Us
    • Privacy Policy
    • Terms And Conditions
    • Contact Us

    follow us

    Subscribe
    Nutraceuticals World

    Latest Breaking News From Nutraceuticals World

    BAPP Paper Reviews Common Adulteration Practices Which Go Undetected
    CRN Announces Promotions and Welcomes New Staff Member
    Quercetin Ingredient Linked to Improved COVID-19 Recovery: Study
    Coatings World

    Latest Breaking News From Coatings World

    PPG Achieves ISO 14001 Certification of Environmental Management System
    AmCoat’s Rhino Shield and Floor Shield Break Records in 2022
    Automotive Industry Leaders Form Cofinity-X JV
    Medical Product Outsourcing

    Latest Breaking News From Medical Product Outsourcing

    The Producto Group Appoints Mark C. Rauenzahn as Chief Executive Officer
    Coloplast Launches New Catheter in the U.S.
    Josh Ghaim and Sachin Jain Join Cue Health Board of Directors
    Contract Pharma

    Latest Breaking News From Contract Pharma

    Jones Healthcare Group Installs BOBST NOVACUT 106 ER Flatbed Die-Cutter
    Pfizer Revenues Soar to Record-Breaking $100B in 2022
    iuvo BioScience Appoints Industry Exec to Lead Lab Biz
    Beauty Packaging

    Latest Breaking News From Beauty Packaging

    Pacifica is our Packager of the Year
    La Roche-Posay Named the Fastest Growing Skincare Brand of 2022 by NielsenIQ
    Disney Collaborates with Nailtopia on Limited-Edition Nail Collection
    Happi

    Latest Breaking News From Happi

    Color Street Launches ‘Through the Cosmos’ Collection
    Curl Care Collection is New at Native
    Color Street Pledges $100K To Support Military & Veteran Appreciation
    Ink World

    Latest Breaking News From Ink World

    International Paper Reports Full-Year, 4Q 2022 Results
    UFlex Exhibits Sustainable Printing, Packaging Solutions at Plast India 2023
    Early-Bird Registration Opens for Print UV 2023
    Label & Narrow Web

    Latest Breaking News From Label & Narrow Web

    SABIC announces value chain partnerships
    Digital Embellishment Alliance launches new website community
    FLAG achieves record membership in 2022
    Nonwovens Industry

    Latest Breaking News From Nonwovens Industry

    Superior Felt & Filtration Adds Domestic Injection Molding to its Medical Filtration Capabilities
    Ahlstrom Launches New Generation FluoroFree Technology
    Berry to Begin Production at India Healthcare Hub Early This Year
    Orthopedic Design & Technology

    Latest Breaking News From Orthopedic Design & Technology

    Mobi-C Cervical Disc Replacement Procedures Top 200,000
    OPUM, Corflex Global Partner on Knee Assessment Technology
    ODT's Most-Read Stories This Week—Jan. 28
    Printed Electronics Now

    Latest Breaking News From Printed Electronics Now

    Johan Hjertonsson Proposed as New Chairman of ASSA ABLOY
    Durak Highlights SilverPro Conductive Threads
    Arkema Partners with Research Institute to Open Lab in Mulhouse, France

    Copyright © 2023 Rodman Media. All rights reserved. Use of this constitutes acceptance of our privacy policy The material on this site may not be reproduced, distributed, transmitted, or otherwise used, except with the prior written permission of Rodman Media.

    AD BLOCKER DETECTED

    Our website is made possible by displaying online advertisements to our visitors.
    Please consider supporting us by disabling your ad blocker.


    FREE SUBSCRIPTION Already a subscriber? Login