• Login
    • Join
  • FOLLOW:
  • Subscribe Free
    • Magazine
    • eNewsletter
    Checkout
    • Magazine
    • News
    • Opinions
    • Top 30
    • Research
    • Supply Chain
    • Device Sectors
    • Directory
    • Events
    • Resources
    • Microsites
    • More
  • Magazine
  • News
  • Opinions
  • Top 30
  • Research
  • Supply Chain
  • Device Sectors
  • Directory
  • Events
  • Resources
  • Microsites
  • Current / Back Issues
    Features
    Editorial
    Digital Edition
    eNewsletter Archive
    Our Team
    Editorial Guidelines
    Reprints
    Subscribe Now
    Advertise Now
    Top Features
    MPO's 2023 Medical Device Industry Year in Review

    The Beat Goes On in the Cardiovascular Device Market

    Medical Manufacturers Gain Support from 3D Printing

    The Intelligent Tools Medical Device Manufacturers Already Own

    MPO's 2023 Medtech Supply Chain Survey
    OEM News
    Supplier News
    Service / Press Releases
    Online Exclusives
    Press Releases
    People in the News
    Product & Service Releases
    Supplier News
    Medtech Makers
    Technical Features
    International News
    Videos
    Product & Service Releases
    Live From Shows
    Regulatory
    Financial/Business
    Top News
    TT Electronics Receives FDA Registration for China Facility

    Beta Bionics to Launch iLet Bionic Pancreas with Dexcom G7 CGM System

    Edwards to Spin Off Critical Care Biz in 2024

    Nortech Systems Suzhou Facility Now Certified for Class II Medical Devices

    KORU Medical Systems Recruits Edward Wholihan to Its Board
    From the Editor
    Blogs
    Guest Opinions
    Top Opinions
    MPO's 2023 Medical Device Industry Year in Review

    The Beat Goes On in the Cardiovascular Device Market

    Medical Manufacturers Gain Support from 3D Printing

    The Intelligent Tools Medical Device Manufacturers Already Own

    MPO's 2023 Medtech Supply Chain Survey
    Top 30 Medical Device Companies
    Market Data
    White Papers
    Top Research
    A Peek Into the 2028 MPO Summit

    Retail Healthcare Disruptors and Medical Devices

    Six Developments Your Talent Strategy Should Prepare for in 2024

    The Power and Paradox of Never

    Navigating the Q-Sub Program: How Experienced Lab Partners Can Help Streamline Regulatory Submission
    3D/Additive Manufacturing
    Contract Manufacturing
    Electronics
    Machining & Laser Processing
    Materials
    Molding
    Packaging & Sterilization
    R&D & Design
    Software & IT
    Testing
    Tubing & Extrusion
    Cardiovascular
    Diagnostics
    Digital Health
    Neurological
    Patient Monitoring
    Surgical
    Orthopedics
    All Companies
    Categories
    Company Capabilities
    Add New Company
    Outsourcing Directory
    Arthur G Russell Company, The

    Medbio LLC

    Poly-Med, Inc.

    maxon

    Halkey-Roberts Corporation
    MPO Summit
    Industry Events
    Webinars
    Live From Show Event
    Industry Associations
    Videos
    Career Central
    eBook
    Slideshows
    Top Resources
    Telemedicine for Neurology: 5 Benefits of Remote Management

    Machining 101: A Review of Machining Components with a Five-Axis System

    MedTech 2024: Top 5 Trends Shaping a Dynamic Industry

    Early Warning: A Q&A with Abbott's CMO of Heart Failure

    2023 in Review: Medtech's Mega-M&A Is MIA
    Companies
    News Releases
    Product Releases
    Press Releases
    Product Spec Sheets
    Service Releases
    Case Studies
    White Papers
    Brochures
    Videos
    Outsourcing Directory
    Arthur G Russell Company, The

    Medbio LLC

    Poly-Med, Inc.

    maxon

    Halkey-Roberts Corporation
    • Magazine
      • Current/Back Issues
      • Features
      • Editorial
      • Columns
      • Digital Editions
      • Subscribe Now
      • Advertise Now
    • News
    • Directory
      • All Companies
      • ALL CATEGORIES
      • Industry Associations
      • Company Capabilities
      • Add Your Company
    • Supply Chain
      • 3D/Additive Manufacturing
      • Contract Manufacturing
      • Electronics
      • Machining & Laser Processing
      • Materials
      • Molding
      • Packaging & Sterilization
      • R&D & Design
      • Software & IT
      • Testing
      • Tubing & Extrusion
    • Device Sectors
      • Cardiovascular
      • Diagnostics
      • Digital Health
      • Neurological
      • Patient Monitoring
      • Surgical
      • Orthopedics
    • Top 30 Company Report
    • Expert Insights
    • Slideshows
    • Videos
    • eBook
    • Resources
    • Podcasts
    • Infographics
    • Whitepapers
    • Research
      • White Papers
      • Case Studies
      • Product Spec Sheets
      • Market Data
    • MPO Summit
    • Events
      • Industry Events
      • Live From Show Events
      • Webinars
    • Microsite
      • Companies
      • Product Releases
      • Product Spec Sheets
      • Services
      • White Papers / Tech Papers
      • Press Releases
      • Videos
      • Literature / Brochures
      • Case Studies
    • About Us
      • About Us
      • Contact Us
      • Advertise with Us
      • eNewsletter Archive
      • Privacy Policy
      • Terms of Use
    Breaking News

    Wireless 'Pacemaker for the Brain' Could Offer New Treatment for Neurological Disorders

    Device fine-tunes treatment by stimulating and recording electric current in the brain at the same time.

    Wireless
    In a proposed device, two of the new chips would be embedded in a chassis located outside the head. Each chip could monitor electrical activity from 64 electrodes located into the brain while simultaneously delivering electrical stimulation to prevent unwanted seizures or tremors. All images courtesy of Rikky Muller, UC Berkeley.
    University of California - Berkeley01.02.19
    A new neurostimulator developed by engineers at the University of California, Berkeley, can listen to and stimulate electric current in the brain at the same time, potentially delivering fine-tuned treatments to patients with diseases like epilepsy and Parkinson's.
     
    The device, named the WAND, works like a "pacemaker for the brain," monitoring the brain's electrical activity and delivering electrical stimulation if it detects something amiss.
     
    These devices can be extremely effective at preventing debilitating tremors or seizures in patients with a variety of neurological conditions. But the electrical signatures that precede a seizure or tremor can be extremely subtle, and the frequency and strength of electrical stimulation required to prevent them are equally touchy. It can take years of small adjustments by doctors before the devices provide optimal treatment.
     
    WAND, which stands for wireless artifact-free neuromodulation device, is both wireless and autonomous, meaning that once it learns to recognize the signs of tremor or seizure, it can adjust the stimulation parameters on its own to prevent the unwanted movements. And because it is closed-loop—meaning it can stimulate and record simultaneously—it can adjust these parameters in real-time.
     
    "The process of finding the right therapy for a patient is extremely costly and can take years. Significant reduction in both cost and duration can potentially lead to greatly improved outcomes and accessibility," said Rikky Muller assistant professor of electrical engineering and computer sciences at Berkeley. "We want to enable the device to figure out what is the best way to stimulate for a given patient to give the best outcomes. And you can only do that by listening and recording the neural signatures."
     
    WAND can record electrical activity over 128 channels, or from 128 points in the brain, compared to eight channels in other closed-loop systems. To demonstrate the device, the team used WAND to recognize and delay specific arm movements in rhesus macaques. The device is described in a study that appeared recently in Nature Biomedical Engineering.


    The WAND chip is designed with custom integrated circuits that can record the full signal from both subtle brain waves and strong electrical pulses delivered by the stimulator.
     
    Ripples in a Pond
    Simultaneously stimulating and recording electrical signals in the brain is much like trying to see small ripples in a pond while also splashing your feet—the electrical signals from the brain are overwhelmed by the large pulses of electricity delivered by the stimulation.
     
    Currently, deep brain stimulators either stop recording while delivering the electrical stimulation, or record at a different part of the brain from where the stimulation is applied—essentially measuring the small ripples at a different point in the pond from the splashing.
     
    "In order to deliver closed-loop stimulation-based therapies, which is a big goal for people treating Parkinson's and epilepsy and a variety of neurological disorders, it is very important to both perform neural recordings and stimulation simultaneously, which currently no single commercial device does," said former UC Berkeley postdoctoral associate Samantha Santacruz, who is now an assistant professor at the University of Texas in Austin.
     
    Researchers at Cortera Neurotechnologies Inc., led by Rikky Muller, designed the WAND custom integrated circuits that can record the full signal from both the subtle brain waves and the strong electrical pulses. This chip design allows WAND to subtract the signal from the electrical pulses, resulting in a clean signal from the brain waves.
     
    Existing devices are tuned to record signals only from the smaller brain waves and are overwhelmed by the large stimulation pulses, making this type of signal reconstruction impossible.
     
    "Because we can actually stimulate and record in the same brain region, we know exactly what is happening when we are providing a therapy," Muller said.
     
    In collaboration with the lab of electrical engineering and computer science professor Jan Rabaey, the team built a platform device with wireless and closed-loop computational capabilities that can be programmed for use in a variety of research and clinical applications.


    WAND's custom integrated circuits.
     
    In experiments led by Santacruz while a postdoc at UC Berkeley, and by electrical engineering and computer science professor Jose Carmena, subjects were taught to use a joystick to move a cursor to a specific location. After a training period, the WAND device was capable of detecting the neural signatures that arose as the subjects prepared to perform the motion, and then deliver electrical stimulation that delayed the motion.
     
    "While delaying reaction time is something that has been demonstrated before, this is, to our knowledge, the first time that it has been demonstrated in a closed-loop system based on a neurological recording only," Muller said.
     
    "In the future, we aim to incorporate learning into our closed-loop platform to build intelligent devices that can figure out how to best treat you, and remove the doctor from having to constantly intervene in this process," said Muller said.
    Related Searches
    • biomedical
    • therapy
    • engineering
    • research
    Related Knowledge Center
    • Neurological
    Suggested For You
    Health Canada Approval for Axonics’ Implantable Neurostimulator Health Canada Approval for Axonics’ Implantable Neurostimulator
    Gentle Probes Could Enable Massive Brain Data Collection Gentle Probes Could Enable Massive Brain Data Collection
    Synchron’s Stentrode Brain-Computer Interface Earns Breakthrough Status Synchron’s Stentrode Brain-Computer Interface Earns Breakthrough Status
    Stryker Launches Surpass Evolve Flow Diverter for Brain Aneurysms Stryker Launches Surpass Evolve Flow Diverter for Brain Aneurysms
    Stryker Stryker's Neuroform Atlas Stent Approved for Back of the Brain Aneurysms
    New Design Principle Could Prevent Brain Shunt Catheter Failure New Design Principle Could Prevent Brain Shunt Catheter Failure
    Brain Scientific Introduces Enhanced NeuroCap Disposable EEG Headset Brain Scientific Introduces Enhanced NeuroCap Disposable EEG Headset
    Thin-Film Electrodes for Brain Surgery Reach the Market Thin-Film Electrodes for Brain Surgery Reach the Market
    Medtronic Sees Revenue Losses Due to COVID-19 Pandemic Medtronic Sees Revenue Losses Due to COVID-19 Pandemic
    Medtronic Recalls Brain Aneurysm Stents Medtronic Recalls Brain Aneurysm Stents
    'Stentrode' Developed for Brain Treatments Without Major Surgery
    RSNA News: University of Vermont Professor Joins RSNA Board of Directors RSNA News: University of Vermont Professor Joins RSNA Board of Directors
     Geneva Health Solutions Launches Geneva University Geneva Health Solutions Launches Geneva University
    Skin-Like Sensor Maps Blood-Oxygen Levels Anywhere in the Body Skin-Like Sensor Maps Blood-Oxygen Levels Anywhere in the Body
    Ultra-High-Field Brain Scanner Gains FDA Nod for Clinical Use Ultra-High-Field Brain Scanner Gains FDA Nod for Clinical Use

    Related Breaking News

    • Neurological
      Health Canada Approval for Axonics’ Implantable Neurostimulator

      Health Canada Approval for Axonics’ Implantable Neurostimulator

      The next generation INS approved by Health Canada reduces how frequently a patient needs to recharge their implanted device to once a month for about one hour.
      Business Wire 09.21.20

    • Neurological
      Gentle Probes Could Enable Massive Brain Data Collection

      Gentle Probes Could Enable Massive Brain Data Collection

      NIH awards $4.15 million grant to maximize use of devices based on flexible nanoelectronic thread.
      Mike Williams, Rice University 09.16.20

    • Neurological
      Synchron’s Stentrode Brain-Computer Interface Earns Breakthrough Status

      Synchron’s Stentrode Brain-Computer Interface Earns Breakthrough Status

      Stentrode is the only investigational, implantable device that does not require open brain surgery.
      Business Wire 08.28.20


    • Neurological
      Stryker Launches Surpass Evolve Flow Diverter for Brain Aneurysms

      Stryker Launches Surpass Evolve Flow Diverter for Brain Aneurysms

      According to the company, the device is the first 64-wire cobalt chromium flow diverter in the U.S. for treating brain aneurysms.
      PR Newswire 08.24.20

    • Cardiovascular | Neurological
      Stryker

      Stryker's Neuroform Atlas Stent Approved for Back of the Brain Aneurysms

      Aneurysms in the posterior circulation rupture more frequently and are generally more difficult to treat.
      PR Newswire 08.07.20

    Loading, Please Wait..

    Breaking News
    • TT Electronics Receives FDA Registration for China Facility
    • Beta Bionics to Launch iLet Bionic Pancreas with Dexcom G7 CGM System
    • Edwards to Spin Off Critical Care Biz in 2024
    • Nortech Systems Suzhou Facility Now Certified for Class II Medical Devices
    • KORU Medical Systems Recruits Edward Wholihan to Its Board
    View Breaking News >
    CURRENT ISSUE

    November 2023

    • MPO's 2023 Medical Device Industry Year in Review
    • The Beat Goes On in the Cardiovascular Device Market
    • Medical Manufacturers Gain Support from 3D Printing
    • The Intelligent Tools Medical Device Manufacturers Already Own
    • View More >

    Cookies help us to provide you with an excellent service. By using our website, you declare yourself in agreement with our use of cookies.
    You can obtain detailed information about the use of cookies on our website by clicking on "More information”.

    • About Us
    • Privacy Policy
    • Terms And Conditions
    • Contact Us

    follow us

    Subscribe
    Nutraceuticals World

    Latest Breaking News From Nutraceuticals World

    FDA Issues Interim Response to Nammex’s Mushroom Labeling Petition
    MSM Linked to Improvements in Knee Pain
    Lion’s Mane Extract Linked to Better Cognitive Performance, Subjective Stress
    Coatings World

    Latest Breaking News From Coatings World

    Interpon Helps Italian Aluminum Coating Business DFV Accelerate Sustainability Plans
    AkzoNobel and China’s Wuxi El Pont Exploring Use of Electron Beams to Cure Coatings
    Wayne E. Jones Jr. to Serve as Chair of ACS Board of Directors
    Medical Product Outsourcing

    Latest Breaking News From Medical Product Outsourcing

    TT Electronics Receives FDA Registration for China Facility
    Beta Bionics to Launch iLet Bionic Pancreas with Dexcom G7 CGM System
    Edwards to Spin Off Critical Care Biz in 2024
    Contract Pharma

    Latest Breaking News From Contract Pharma

    Innovent Biologics, Synaffix Expand ADC Licensing Deal
    AbelZeta, AstraZeneca Partner on Novel GPC3 Armored CAR-T Therapy
    AbbVie to Acquire Cerevel Therapeutics for $8.7B
    Beauty Packaging

    Latest Breaking News From Beauty Packaging

    P&G to Incur $2.5 Billion Charge Over Next Two Years
    Natural Skincare Products Market Forecasted to Reach $13.4B by 2032
    Respect Wellness Introduces Facial Balm for Women Navigating Menopause
    Happi

    Latest Breaking News From Happi

    Wet & Forget USA Recalls 2.7 Million Bottles of ‘Xtreme Reach’ Outdoor Mold & Mildew Stain Remover
    Procter & Gamble To Take $2.5 Billion Restructuring Charge
    Shin-Etsu Silicones Premieres Advanced Sensory Sunscreen Formulations
    Ink World

    Latest Breaking News From Ink World

    New INX Sustainability Report Details Present, Future Commitments
    Siegwerk Reshapes Leadership Team
    Wayne E. Jones Jr. Named Chair of ACS Board of Directors
    Label & Narrow Web

    Latest Breaking News From Label & Narrow Web

    UPM Raflatac releases neuromarketing study findings
    INX releases inaugural Sustainability Report
    IDENTCO appoints Brian Kady VP of global sales
    Nonwovens Industry

    Latest Breaking News From Nonwovens Industry

    Ginni Strikes Deal to Sell Spinning, Knitting Operations
    Campen Machinery Announces Patent Pending Status for Airlaid Trays
    Veocel Partners with Beauty and Feminine Care Brands in Asia Pacific
    Orthopedic Design & Technology

    Latest Breaking News From Orthopedic Design & Technology

    Wenzel Spine Hires Dr. Robert Gordon as Executive Chairman
    Dr. Srikant Datar to Retire from Stryker's Board of Directors
    HOPCo Acquires MyACTome Digital Health Platform
    Printed Electronics Now

    Latest Breaking News From Printed Electronics Now

    ASSA ABLOY Acquires Ghost Controls
    SCHOTT Invests at Its Landshut, Germany Site
    TOPPAN to Build Line for Semiconductors Packages

    Copyright © 2023 Rodman Media. All rights reserved. Use of this constitutes acceptance of our privacy policy The material on this site may not be reproduced, distributed, transmitted, or otherwise used, except with the prior written permission of Rodman Media.

    AD BLOCKER DETECTED

    Our website is made possible by displaying online advertisements to our visitors.
    Please consider supporting us by disabling your ad blocker.


    FREE SUBSCRIPTION Already a subscriber? Login