• Login
    • Join
  • FOLLOW:
  • Subscribe Free
    • Magazine
    • eNewsletter
    Checkout
    • Magazine
    • News
    • Opinions
    • Top 30
    • Research
    • Supply Chain
    • Device Sectors
    • Directory
    • Events
    • Resources
    • Microsites
    • More
  • Magazine
  • News
  • Opinions
  • Top 30
  • Research
  • Supply Chain
  • Device Sectors
  • Directory
  • Events
  • Resources
  • Microsites
  • Current / Back Issues
    Features
    Editorial
    Digital Edition
    eNewsletter Archive
    Our Team
    Editorial Guidelines
    Reprints
    Subscribe Now
    Advertise Now
    Top Features
    Computer Concepts for Medical Device Design

    IVD Manufacturers Are Being Put to the Test

    The New State of Medtech Outsourcing

    The Changing Face of Medtech Surface Treatment

    The Totally Tubular Technologies that Support Medical Devices
    OEM News
    Supplier News
    Service / Press Releases
    Online Exclusives
    Press Releases
    People in the News
    Product & Service Releases
    Supplier News
    Medtech Makers
    Technical Features
    International News
    Videos
    Product & Service Releases
    Live From Shows
    Regulatory
    Financial/Business
    Top News
    Vascular Surgeon Imprisoned and Fined for Decade-Long Healthcare Fraud

    Remote Monitoring, Digital Health Help Advance Wound Care Treatment

    MLM Biologics Developing Wound Infection Prevention Device for Military

    NovaScan, PHC Corporation Working on Skin Cancer Detection Device

    Ur24Technology Granted Medicare Reimbursement for External Catheter System
    From the Editor
    Blogs
    Guest Opinions
    Top Opinions
    Computer Concepts for Medical Device Design

    IVD Manufacturers Are Being Put to the Test

    The New State of Medtech Outsourcing

    The Changing Face of Medtech Surface Treatment

    The Totally Tubular Technologies that Support Medical Devices
    Top 30 Medical Device Companies
    Market Data
    White Papers
    Top Research
    Checking Up on Surgical Robotics

    Building a Network: How Synchron Is Developing a New Device—and a New Market

    Six Lessons Learned on Developing a Strong Company Culture

    As Hiring Slows, Companies Look Inward to Fulfill Talent Needs

    Artificial Intelligence: Medtech Opportunity or Health Danger?
    3D/Additive Manufacturing
    Contract Manufacturing
    Electronics
    Machining & Laser Processing
    Materials
    Molding
    Packaging & Sterilization
    R&D & Design
    Software & IT
    Testing
    Tubing & Extrusion
    Cardiovascular
    Diagnostics
    Digital Health
    Neurological
    Patient Monitoring
    Surgical
    Orthopedics
    All Companies
    Categories
    Company Capabilities
    Add New Company
    Outsourcing Directory
    Halkey-Roberts Corporation

    NDH Medical Inc.

    LEMO USA Inc.

    Fusion Biotec Inc.

    Cirtec Medical
    MPO Summit
    Industry Events
    Webinars
    Live From Show Event
    Industry Associations
    Videos
    Career Central
    eBook
    Slideshows
    Top Resources
    3 Key Elements to Consider When Managing a Medtech Sales Force

    Tech-Enabled Virtual Speech Therapy Improves Speech & Communication Skills

    Practical Strategies for Digitization and Integration in Medtech Manufacturing

    Sensors: The Heart of Minimally Invasive Equipment Technology

    Optimizing UX for the Internet of Medical Things
    Companies
    News Releases
    Product Releases
    Press Releases
    Product Spec Sheets
    Service Releases
    Case Studies
    White Papers
    Brochures
    Videos
    Outsourcing Directory
    Halkey-Roberts Corporation

    NDH Medical Inc.

    LEMO USA Inc.

    Fusion Biotec Inc.

    Cirtec Medical
    • Magazine
      • Current/Back Issues
      • Features
      • Editorial
      • Columns
      • Digital Editions
      • Subscribe Now
      • Advertise Now
    • News
    • Directory
      • All Companies
      • ALL CATEGORIES
      • Industry Associations
      • Company Capabilities
      • Add Your Company
    • Supply Chain
      • 3D/Additive Manufacturing
      • Contract Manufacturing
      • Electronics
      • Machining & Laser Processing
      • Materials
      • Molding
      • Packaging & Sterilization
      • R&D & Design
      • Software & IT
      • Testing
      • Tubing & Extrusion
    • Device Sectors
      • Cardiovascular
      • Diagnostics
      • Digital Health
      • Neurological
      • Patient Monitoring
      • Surgical
      • Orthopedics
    • Top 30 Company Report
    • Expert Insights
    • Slideshows
    • Videos
    • eBook
    • Resources
    • Podcasts
    • Infographics
    • Whitepapers
    • Research
      • White Papers
      • Case Studies
      • Product Spec Sheets
      • Market Data
    • MPO Summit
    • Events
      • Industry Events
      • Live From Show Events
      • Webinars
    • Microsite
      • Companies
      • Product Releases
      • Product Spec Sheets
      • Services
      • White Papers / Tech Papers
      • Press Releases
      • Videos
      • Literature / Brochures
      • Case Studies
    • About Us
      • About Us
      • Contact Us
      • Advertise with Us
      • eNewsletter Archive
      • Privacy Policy
      • Terms of Use
    Breaking News

    In a Sample of Blood, Researchers Probe for Cancer Clues

    A microfluidic device breaks cells open and tests the cellular contents for eight cancer protein biomarkers.

    03.24.17
    One day, patients may be able to monitor their body's response to cancer therapy just by having their blood drawn. A new study, led by bioengineers at UC Berkeley, has taken an important step in that direction by measuring a panel of cancer proteins in rare, individual tumor cells that float in the blood.
     
    Berkeley researchers isolated circulating tumor cells from the blood of breast cancer patients, then used microscale physics to design a precision test for protein biomarkers, which are indicators of cancer. After isolating each cell, the microfluidic device breaks the cells open and tests the cellular contents for eight cancer protein biomarkers. The researchers are expanding the number of proteins identifiable with this technology to eventually allow pathologists to classify cancer cells more precisely than is possible using existing biomarkers.
     
    "Tremendous advances have been made in DNA and RNA profiling in cells collected using a liquid biopsy. We extend those advances to highly selective measurement of proteins - the 'molecular machines' of the cell," said Amy Herr, a Berkeley bioengineering professor and leader of the study team. "We are working to create medicine that would allow a doctor to monitor a patient's treatment response through a blood draw, perhaps on a daily basis."
     
    The study was published March 23 in the journal Nature Communications. The research was a collaboration with breast cancer surgeon Stefanie Jeffrey at Stanford University and with a University of California startup, Vortex Biosciences. Funding was provided by the National Cancer Institute of the National Institutes of Health.
     
    The study focuses on circulating tumor cells, a potentially rich source of information about a person's cancer. These cells are thought to break off from the original tumor and circulate in the blood, and may be a sign of an aggressive tumor. But studying these cells is difficult because the cells are rare, so few are collected even when enriched from the blood. The cells contain different proteins than the original tumor, so research is ongoing to unlock the secrets of these elusive cells.
     
    To better study circulating tumor cells, the researchers collaborated with physician-scientists and industry engineers to develop a microfluidics system that separates these large cells into a concentrated sample. A key advance the team made was in devising a system to precisely handle and manipulate the concentrated cells from blood. The Berkeley researchers then analyzed each circulating tumor cell for the specific panel of cancer proteins.
     
    To do so, they placed each rare cell in a microwell (with a diameter roughly half the width of a human hair). Once settled in the microwell, the circulating tumor cells were burst open and the proteins released from inside each cell were separated according to differences in size or mass. The scientists were then able to identify cancer proteins by introducing fluorescent probes that bind to and light up a specific protein target. By sorting and probing the protein targets, the test is more selective than existing pathology tools. Enhanced selectivity will be crucial in detecting subtle chemical modifications to biomarkers that can be important but difficult to measure, Herr said. The researchers plan to expand their approach to identify more proteins, and proteins with unique modifications, in circulating tumor cells.
     
    "Microfluidic design was key in this study. We were able to integrate features needed for each measurement stage into one process," Herr said. "Systems integration allowed us to do every single measurement step very, very quickly while the biomarkers are still concentrated. If not performed exceptionally fast, the cell's proteins diffuse away and become undetectable."
     
    Related Searches
    • design
    • tumor
    • health
    • stanford
    Related Knowledge Center
    • Diagnostics
    Suggested For You
    Diagnostic May Bring Faster, Cheaper Cancer Testing to Remote Settings Diagnostic May Bring Faster, Cheaper Cancer Testing to Remote Settings
    Application Detects Cancer Cells in Abdominal Cavity in Real Time Application Detects Cancer Cells in Abdominal Cavity in Real Time
    New AI New AI 'Smart Pill' Images Gut to Spot Cancer
    Study: Whole Breast Ultrasound Tomography Improves Breast Cancer Risk Assessment Study: Whole Breast Ultrasound Tomography Improves Breast Cancer Risk Assessment
    Hologic Granted EUA for Second COVID-19 Molecular Test Hologic Granted EUA for Second COVID-19 Molecular Test
    World World's First Saliva Test Spots Hidden Throat Cancer
    Medtech’s Battle on Multiple Fronts Against COVID-19 Medtech’s Battle on Multiple Fronts Against COVID-19
    Blood Test May Help Doctors Catch Pancreatic Cancer Early Blood Test May Help Doctors Catch Pancreatic Cancer Early
    FDA Grants Lucid Diagnostics Breakthrough Device Designation for Esophageal DNA Test FDA Grants Lucid Diagnostics Breakthrough Device Designation for Esophageal DNA Test
    Research Shows New Active Drain Line Clearance System Improves Data Accuracy Research Shows New Active Drain Line Clearance System Improves Data Accuracy
    Competition Seeks Development of Human Eye Tissue in a Dish Competition Seeks Development of Human Eye Tissue in a Dish
    Artificial Womb Could Decrease Premature Babies Artificial Womb Could Decrease Premature Babies' Mortality and Disability
    Nanodiamonds Are an MRI Nanodiamonds Are an MRI's Best Friend
    Personalized 3D Brain Maps to Guide Neurosurgeries Personalized 3D Brain Maps to Guide Neurosurgeries
    New Gene-Based Blood Tests Identify More Skin Cancers New Gene-Based Blood Tests Identify More Skin Cancers

    Related Breaking News

    • Chronic Disease | Diagnostics
      Diagnostic May Bring Faster, Cheaper Cancer Testing to Remote Settings

      Diagnostic May Bring Faster, Cheaper Cancer Testing to Remote Settings

      The CytoPAN is used to study breast cells gathered with fine-needle aspiration, a less invasive alternative to standard biopsies.
      American Association for the Advancement of Science 08.07.20

    • Chronic Disease | Diagnostics
      Application Detects Cancer Cells in Abdominal Cavity in Real Time

      Application Detects Cancer Cells in Abdominal Cavity in Real Time

      New approach from Tel Aviv University combines medicine, engineering, and computer science.
      American Friends of Tel Aviv University 07.23.20

    • Diagnostics
      New AI

      New AI 'Smart Pill' Images Gut to Spot Cancer

      Now in prototype development, SmartCap is a new generation diagnostic tool.
      University of Saskatchewan 07.09.20


    • Study: Whole Breast Ultrasound Tomography Improves Breast Cancer Risk Assessment

      Study: Whole Breast Ultrasound Tomography Improves Breast Cancer Risk Assessment

      Researchers compared mammography and whole breast ultrasound in younger women with dense breast tissue.
      Business Wire 05.18.20

    • Diagnostics
      Hologic Granted EUA for Second COVID-19 Molecular Test

      Hologic Granted EUA for Second COVID-19 Molecular Test

      Significant test manufacturing capacity, large installed base of automated instruments yield testing breakthrough.
      Business Wire 05.15.20

    Loading, Please Wait..

    Trending
    • Vascular Surgeon Imprisoned And Fined For Decade-Long Healthcare Fraud
    • Philips Names New Supervisory Board Chairman
    • A New Approach To Post-Market Surveillance
    • Healthcare Changes Prompt Medtronic To Merge Sales Force Medtronic, Inc. Is Combining Its U.S. Ca
    • FDA Clears LiveMetric's Wearable Blood Pressure Monitoring Tech
    Breaking News
    • Vascular Surgeon Imprisoned and Fined for Decade-Long Healthcare Fraud
    • Remote Monitoring, Digital Health Help Advance Wound Care Treatment
    • MLM Biologics Developing Wound Infection Prevention Device for Military
    • NovaScan, PHC Corporation Working on Skin Cancer Detection Device
    • Ur24Technology Granted Medicare Reimbursement for External Catheter System
    View Breaking News >
    CURRENT ISSUE

    May 2023

    • Computer Concepts for Medical Device Design
    • IVD Manufacturers Are Being Put to the Test
    • The New State of Medtech Outsourcing
    • View More >

    Cookies help us to provide you with an excellent service. By using our website, you declare yourself in agreement with our use of cookies.
    You can obtain detailed information about the use of cookies on our website by clicking on "More information”.

    • About Us
    • Privacy Policy
    • Terms And Conditions
    • Contact Us

    follow us

    Subscribe
    Nutraceuticals World

    Latest Breaking News From Nutraceuticals World

    Premium Label & Packaging Solutions Receives Safe Quality Food (SQF) Certification
    Inulinase Enzymes May Benefit Gut Symptoms of FODMAP Digestion
    Verdure Sciences’ Boswellia Ingredient Receives USP Verification
    Coatings World

    Latest Breaking News From Coatings World

    OQ Chemicals Launches Cost-Cutting Program and Organizational Realignment in Germany
    BASF Strengthens R&D with More Powerful Supercomputer
    Safic-Alcan Expands its Presence in Africa with the Launch of Safic-Alcan East Africa in Kenya
    Medical Product Outsourcing

    Latest Breaking News From Medical Product Outsourcing

    Vascular Surgeon Imprisoned and Fined for Decade-Long Healthcare Fraud
    Remote Monitoring, Digital Health Help Advance Wound Care Treatment
    MLM Biologics Developing Wound Infection Prevention Device for Military
    Contract Pharma

    Latest Breaking News From Contract Pharma

    Catalent Adds New Cryogenic Capabilities at Japanese Facility
    Lifecore Biomedical Enters into $150M New Financing Deal
    WuXi Biologics Receives 2023 ISPE Facility of the Year Award
    Beauty Packaging

    Latest Breaking News From Beauty Packaging

    How Robots & Artificial Intelligence are Transforming Unilever's Material Innovation Factory
    Top 10 Most Popular Hair Care Brands in the U.S.—Ranked by Searches
    Aloette Cosmetics Launches Daily Mineral Shield Sunscreen
    Happi

    Latest Breaking News From Happi

    Revieve Launches Beauty Technology Platform on Google Cloud Marketplace
    BBW’s Fabric Softener Launch, Ameon’s New Ambassador
    Mielle Organics Taps Angel Reese as New Ambassador
    Ink World

    Latest Breaking News From Ink World

    Weekly Recap: INX Digital, Mexar and hubergroup Top This Week’s Stories
    Richnerstutz AG Acquires an EFI VUTEk Q5r Superwide Roll-to-Roll Printer
    BASF Strengthens Its R&D with More Powerful Supercomputer
    Label & Narrow Web

    Latest Breaking News From Label & Narrow Web

    Mactac acquires Label Supply, Beontag grows and more
    Sun Chemical releases Spring 2023 Regulatory Newsletter
    Tageos unveils new RAIN RFID inlays
    Nonwovens Industry

    Latest Breaking News From Nonwovens Industry

    Weekly Recap: Corman, Tosama Develop Biodegradable Plastic Tampon Applicator, Trevira Changes Name
    Suominen Appoints SVP, Transformation Management Office
    Minnesota Signs PFAS Ban in Consumer Products
    Orthopedic Design & Technology

    Latest Breaking News From Orthopedic Design & Technology

    AlloSource Launches AlloMend Duo Acellular Dermal Matrix
    TendoNova Inks Partnership With AcCELLerated Biologics
    Stryker Achieves First Surgeries Using Q Guidance System with Cranial Guidance Software
    Printed Electronics Now

    Latest Breaking News From Printed Electronics Now

    Weekly Recap: Smart Skis, Universal Display Top This Week’s Stories
    Wiliot Appoints Antony Yousefian as VP of Climate & Circularity
    HID Unveils Eco-friendly Bamboo Access Cards

    Copyright © 2023 Rodman Media. All rights reserved. Use of this constitutes acceptance of our privacy policy The material on this site may not be reproduced, distributed, transmitted, or otherwise used, except with the prior written permission of Rodman Media.

    AD BLOCKER DETECTED

    Our website is made possible by displaying online advertisements to our visitors.
    Please consider supporting us by disabling your ad blocker.


    FREE SUBSCRIPTION Already a subscriber? Login