• Login
    • Join
  • FOLLOW:
  • Subscribe Free
    • Magazine
    • eNewsletter
    Checkout
    • Magazine
    • News
    • Opinions
    • Top 30
    • Research
    • Supply Chain
    • Device Sectors
    • Directory
    • Events
    • Resources
    • Microsites
    • More
  • Magazine
  • News
  • Opinions
  • Top 30
  • Research
  • Supply Chain
  • Device Sectors
  • Directory
  • Events
  • Resources
  • Microsites
  • Current / Back Issues
    Features
    Editorial
    Digital Edition
    eNewsletter Archive
    Our Team
    Editorial Guidelines
    Reprints
    Subscribe Now
    Advertise Now
    Top Features
    The Changing Face of Medtech Surface Treatment

    The Totally Tubular Technologies that Support Medical Devices

    Simply Stimulating: Examining the Neurostimulation Sector

    Sensing Technology Drives the Future of Medical Care

    New and Developing Diabetes Technologies Offer 'Sweet Relief'
    OEM News
    Supplier News
    Service / Press Releases
    Online Exclusives
    Press Releases
    People in the News
    Product & Service Releases
    Supplier News
    Medtech Makers
    Technical Features
    International News
    Videos
    Product & Service Releases
    Live From Shows
    Regulatory
    Financial/Business
    Top News
    Apply Now: Junkosha's Technology Innovator of the Year Awards 2023

    SIS Medical's OPN NC PTCA Dilatation Catheter Released in U.S.

    Digital Transformation Weighs Heavy in Medtech Regulatory Performance

    CCS Establishes Scientific Advisory Council

    Aluna Raises $15.3 Million in Series B Funding
    From the Editor
    Blogs
    Guest Opinions
    Top Opinions
    The Changing Face of Medtech Surface Treatment

    The Totally Tubular Technologies that Support Medical Devices

    Simply Stimulating: Examining the Neurostimulation Sector

    Sensing Technology Drives the Future of Medical Care

    New and Developing Diabetes Technologies Offer 'Sweet Relief'
    Top 30 Medical Device Companies
    Market Data
    White Papers
    Top Research
    Timeline Mystery for Updated EtO Rules

    An Update on Hospital Trends Post-Pandemic

    Don’t Fear the Audit: Benefits of Good Quality Practices

    Understanding the FDA’s Standards & Conformity Assessment Program

    Medtech Divestitures Are Good for Medtech Innovation
    3D/Additive Manufacturing
    Contract Manufacturing
    Electronics
    Machining & Laser Processing
    Materials
    Molding
    Packaging & Sterilization
    R&D & Design
    Software & IT
    Testing
    Tubing & Extrusion
    Cardiovascular
    Diagnostics
    Digital Health
    Neurological
    Patient Monitoring
    Surgical
    Orthopedics
    All Companies
    Categories
    Company Capabilities
    Add New Company
    Outsourcing Directory
    LEMO USA Inc.

    JBC Technologies

    Cirtec Medical

    Providence Enterprise USA Inc.

    NDH Medical Inc.
    MPO Summit
    Industry Events
    Webinars
    Live From Show Event
    Industry Associations
    Videos
    Career Central
    eBook
    Slideshows
    Top Resources
    Designing for Manufacturing: 5 Common Startup Mistakes (and How to Avoid Them)

    5 Challenges Medtech Must Address to Transform Health Care

    3D Printing Medical Devices Revolutionized Manufacturing

    5 Current Trends in Medical Device Security

    How Advanced Sensors Improve Design & Functionality of Respiratory Care Equipment
    Companies
    News Releases
    Product Releases
    Press Releases
    Product Spec Sheets
    Service Releases
    Case Studies
    White Papers
    Brochures
    Videos
    Outsourcing Directory
    LEMO USA Inc.

    JBC Technologies

    Cirtec Medical

    Providence Enterprise USA Inc.

    NDH Medical Inc.
    • Magazine
      • Current/Back Issues
      • Features
      • Editorial
      • Columns
      • Digital Editions
      • Subscribe Now
      • Advertise Now
    • News
    • Directory
      • All Companies
      • ALL CATEGORIES
      • Industry Associations
      • Company Capabilities
      • Add Your Company
    • Supply Chain
      • 3D/Additive Manufacturing
      • Contract Manufacturing
      • Electronics
      • Machining & Laser Processing
      • Materials
      • Molding
      • Packaging & Sterilization
      • R&D & Design
      • Software & IT
      • Testing
      • Tubing & Extrusion
    • Device Sectors
      • Cardiovascular
      • Diagnostics
      • Digital Health
      • Neurological
      • Patient Monitoring
      • Surgical
      • Orthopedics
    • Top 30 Company Report
    • Expert Insights
    • Slideshows
    • Videos
    • eBook
    • Resources
    • Podcasts
    • Infographics
    • Whitepapers
    • Research
      • White Papers
      • Case Studies
      • Product Spec Sheets
      • Market Data
    • MPO Summit
    • Events
      • Industry Events
      • Live From Show Events
      • Webinars
    • Microsite
      • Companies
      • Product Releases
      • Product Spec Sheets
      • Services
      • White Papers / Tech Papers
      • Press Releases
      • Videos
      • Literature / Brochures
      • Case Studies
    • About Us
      • About Us
      • Contact Us
      • Advertise with Us
      • eNewsletter Archive
      • Privacy Policy
      • Terms of Use
    Breaking News

    Erasing the Line Between Imaging and Analyzing

    Biomedical imaging/sensing used to study everything from the development of artificial vision systems to bone biomechanics.

    Erasing the Line Between Imaging and Analyzing
    Christine Hendon’s laboratory has developed automated algorithms to analyze fiber organization within various organ structures, including the heart and cervix (shown). (Credit: Christine Hendon/Columbia Engineering)
    Ann Rae Jonas, Columbia University School of Engineering and Applied Science12.12.16
    As imaging and sensing technologies grow in both sophistication and accessibility, they do more than just gather data and produce images: They are research tools in their own right, providing scientists with the means to deepen our knowledge both about fundamental biological processes and about causes and progression of disease. Obtaining the images is only the first step. Significant research and clinical advances require new ways of analyzing the data.
     
    Current biomedical imaging and sensing technologies include computerized tomography, magnetic resonance imaging, optical coherence tomography, spectroscopy, and ultrasound, to name only a few.
     
    These technologies are at the intersection of the physical sciences, mathematics, computer science, and engineering. Columbia Engineering is home to many imaging and sensing labs, some of which collaborate with labs at Columbia University Medical Center. Our researchers are using biomedical imaging and sensing to study everything from the development of artificial vision systems to bone biomechanics.
     
    Sometimes they work in partnership with technology companies to develop new imaging and sensing techniques. In a constant feedback loop, faculty and researchers pursue technological advances to satisfy unmet scientific and clinical needs; the new technologies then open their eyes to further questions to explore.
     
    Developing Optical Tools for Surgical Guidance
    Early in her research career, Christine Hendon was drawn to biomedical optics; she was intrigued by this medical technology that did not rely on radiation. Today, her overall goal is to develop optical tools for surgical guidance.
     
    “We want to develop optical tools that provide the surgeon with a clear understanding of the tissue,” said Hendon, assistant professor of electrical engineering. Her techniques primarily use near-infrared spectroscopy and optical coherence tomography (OCT), which has been dubbed “optical ultrasound.”
     

    Christine Hendon (left) and Xinwen Yao reviewing histology images of the heart to correlate with optical images taken with a custom-built, ultrahigh resolution optical coherence tomography imaging system. (Credit: Jeffrey Schifman for Columbia Engineering)
    So-called optical biopsies would offer much higher resolution than current biopsy surrogates such as MRIs, PET tomography, and ultrasound. A potential advantage of OCT is that the surgeon would be able to image a wide area of tissue and, unlike with invasive biopsies, remove as little tissue as possible.
     
    Currently, the main application of Hendon’s research is focusing on OCT in the treatment of heart arrhythmias, or irregular heart rhythms. A common treatment is ablation, in which the surgeon uses a catheter to detect abnormal electrical signals and then applies radiofrequency energy to remove scar tissue in the malfunctioning area.
     
    Hendon is also using spectroscopy to provide real-time information during surgery. Especially important is the depth of a lesion—the ablated, or dead, tissue area. “Frequently,” said Hendon, “patients who have ablation return for a second procedure. We hope that the use of spectroscopy will reduce both procedure time and the number of repeat procedures.”
     
    In late July, Hendon did the first in vivo testing of the spectroscopy catheter on an animal model.
     
    Hendon’s group is building an atlas of OCT heart images. So far, the atlas includes 25 human hearts, with 15 volumes (600 images per volume) for each heart. Eventually, the atlas will be used to train cardiologists.
     
    An upcoming project focuses on the use of optical tools in breast cancer. Hendon is working with breast surgeon Sheldon Feldman and pathologist Hanina Hibshoosh at Columbia University Medical Center to identify tumors localized to the duct. Eventually, they will image lesions over time to determine which are likely to progress to cancer.
     
    Hendon is also collaborating with fellow Columbia Engineering professor Kristin Myers on using imaging to assess the mechanical properties of the cervix in relation to preterm birth.
     
    Hendon is committed to encouraging STEM education among youth. At Columbia, she hosts campus visits by middle-school students—who leave with OCT images of their finger. “Middle school kids are great,” she said. “They don’t hesitate to ask questions.”
     
    Image Analysis for Both Diagnosis and Treatment Design
    In the mid-1980s, Andrew Laine was a graduate student at Washington University, in St. Louis—and a whiz hacker. At the time, the three major manufacturers of medical imaging equipment used different encrypted (proprietary) codes for breast magnetic resonance imaging (MRI) scans. At his adviser’s prompting, Laine cracked the codes, so the data from the various machines could be integrated and the images compared and studied. “Later,” he said, “the federal government ordered imaging manufacturers to adopt a common standard, so images could be shared among VA hospitals.” The result was Digital Imaging and Communications in Medicine (DICOM).
     
    International politics played a role in determining Laine’s next step. With the collapse of the Soviet Union, the U.S. army had a surplus in the defense budget, including $20 million for medical research on women’s diseases. Laine proposed a method to enhance mammograms, to address the problem of visible lesions being overlooked in screening. His technology was ranked the most promising in the program, and he received a $2 million grant for mammography research.
     
    Laine, who is chair of the Department of Biomedical Engineering, with a joint appointment in Radiology at Columbia University Medical Center (CUMC), was the first to apply methods of multiscale “wavelet” representations to enhance subtle details in mammograms so they would not be missed. This not only produced better images, but also reduced the amount of radiation needed for screening. Today, the core algorithm he developed in 1992 is used in almost all commercial digital mammography systems worldwide.
     
    Using a phased array ultrasound transducer, Laine was also the first to compute cardiac strain, which can be a precursor to a heart attack, in real time, from 4D (3D plus time) ultrasound. The 4D imaging can also detect abnormal wall motion of dead myocardial tissue resulting from a heart attack that has already occurred.
     
    “Fostering the relationship between academia and industry,” Laine said, “is the fastest way to bring technical advances in imaging to clinical practice and improve patient care.” Laine spearheaded a partnership between Columbia and General Electric (GE) to foster translational research. It enables biomedical engineers, clinicians, and GE to jointly address unmet clinical needs that could benefit from advances in MRI technology and other imaging methods.
     
    Laine is also applying the wavelet technique he devised for mammography to pulmonary emphysema, a form of chronic obstructive pulmonary disease (COPD). Conventional computed tomography (CT) methods categorize a patient’s disease as one of three subtypes. In collaboration with Graham Barr, MD (CUMC), Laine’s lab is helping to reveal underlying disease stages of COPD by expanding the number of imaging phenotypes used as biomarkers.
     
    By using 3D imaging of CT data and tens of thousands of CT lung scans, and tracking thousands of patients over a decade, Laine has discovered a richer set of 60–80 subtypes of emphysematic tissue.
     
    Laine is also working with Professors George Hripcsak and Larry Schwartz at CUMC. Their research will allow clinicians to study a patient’s history using both text (electronic health record) and annotated findings derived from medical images. This collaboration adds the new dimension of imaging informatics—including radiomics (the extraction and analysis of quantitative features of images)—to precision medicine, furthering our ability to understand disease processes, create new therapies, and better predict patient outcome.
    Related Searches
    • biopsy
    • standard
    • catheter
    • patient
    Related Knowledge Center
    • Testing
    • R&D & Design
    Suggested For You
    FDA OKs Abbott FDA OKs Abbott's AI OCT Imaging for Vessels in the Heart
    Data Confirm the Accuracy of HeartFlow Planner in Modeling Post-PCI Outcomes Data Confirm the Accuracy of HeartFlow Planner in Modeling Post-PCI Outcomes
    Abbott Launches OCT Virtual Reality Training for Cardiologists Abbott Launches OCT Virtual Reality Training for Cardiologists
    How 3D Printing Could Bend Healthcare How 3D Printing Could Bend Healthcare's Cost Curve
    Completely Removing Breast Tumors in One Surgery Completely Removing Breast Tumors in One Surgery
    Lung Lung 'Organoids' in a Dish Mimic Features of Full-Size Lung
    Lantheus, GE Healthcare Team Up to Develop and Commercialize Flurpiridaz F 18 Lantheus, GE Healthcare Team Up to Develop and Commercialize Flurpiridaz F 18
    Diabetes App Forecasts Blood Sugar Levels Diabetes App Forecasts Blood Sugar Levels
    Lombard Medical Appoints New CEO Lombard Medical Appoints New CEO
    GE Healthcare Acquires Monica Healthcare GE Healthcare Acquires Monica Healthcare
    The Formidable Team of Clinical and Artificial Intelligence The Formidable Team of Clinical and Artificial Intelligence
    FDA Clears ViewRay FDA Clears ViewRay's MRI-Guided Radiation Therapy System
    Ultra-Flexible Probes Form Reliable, Scar-Free Integration with Brain Ultra-Flexible Probes Form Reliable, Scar-Free Integration with Brain
    Enthusiastic Leadership at AdvaMed Enthusiastic Leadership at AdvaMed
    Stable Growth Predicted for Ultrasound Systems Market Stable Growth Predicted for Ultrasound Systems Market

    Related Breaking News

    • Cardiovascular
      FDA OKs Abbott

      FDA OKs Abbott's AI OCT Imaging for Vessels in the Heart

      Ultreon 1.0 Software is the first-of-its-kind imaging software according to the company.
      PR Newswire 08.04.21

    • Cardiovascular
      Data Confirm the Accuracy of HeartFlow Planner in Modeling Post-PCI Outcomes

      Data Confirm the Accuracy of HeartFlow Planner in Modeling Post-PCI Outcomes

      The interactive planning tool enables heart teams to modify vessels virtually and determine the optimal treatment strategy before procedures.
      Business Wire 07.23.21

    • Cardiovascular
      Abbott Launches OCT Virtual Reality Training for Cardiologists

      Abbott Launches OCT Virtual Reality Training for Cardiologists

      VR training improved cath lab staff learning engagement by 45 percent, knowledge retention by 72 percent.
      Abbott Laboratories 12.09.20


    • 3D/Additive Manufacturing | Cardiovascular | Digital Health | Surgical
      How 3D Printing Could Bend Healthcare

      How 3D Printing Could Bend Healthcare's Cost Curve

      It is the ultimate form of personalized medicine, with doctors and surgeons tailoring medical plans to the individual.
      John Menna, VP Global Strategy, Healthcare Logistics, UPS 05.31.17

    • Surgical
      Completely Removing Breast Tumors in One Surgery

      Completely Removing Breast Tumors in One Surgery

      New imaging technique combines light, sound to create detailed images of cells more quickly than current approach.
      Washington University School of Medicine 05.18.17

    Loading, Please Wait..

    Trending
    • Medinbox And Abbott Partner To Increase Efficiency In Electrophysiology Labs
    • Masimo Reveals Freedom Health-Tracking Smartwatch
    • FDA OKs FemDx Medsystems' FalloView Device
    • Getinge’s Cardiosave Faces CE-Certificate Suspension From TÜV SÜD
    • Designing For Manufacturing: 5 Common Startup Mistakes (and How To Avoid Them)
    Breaking News
    • Apply Now: Junkosha's Technology Innovator of the Year Awards 2023
    • SIS Medical's OPN NC PTCA Dilatation Catheter Released in U.S.
    • Digital Transformation Weighs Heavy in Medtech Regulatory Performance
    • CCS Establishes Scientific Advisory Council
    • Aluna Raises $15.3 Million in Series B Funding
    View Breaking News >
    CURRENT ISSUE

    March 2023

    • Sensing Technology Drives the Future of Medical Care
    • New and Developing Diabetes Technologies Offer 'Sweet Relief'
    • Discussing Matters of Substance in Medtech Materials
    • Medical Device Testers Are Caught Up in a Whirlwind
    • View More >

    Cookies help us to provide you with an excellent service. By using our website, you declare yourself in agreement with our use of cookies.
    You can obtain detailed information about the use of cookies on our website by clicking on "More information”.

    • About Us
    • Privacy Policy
    • Terms And Conditions
    • Contact Us

    follow us

    Subscribe
    Nutraceuticals World

    Latest Breaking News From Nutraceuticals World

    Kemin Human Nutrition & Health Acquires Oral Health Ingredient
    Wiley Eliminates Outer Carton From Packaging to Reduce Waste
    ACG Expands as Vantage Nutrition Acquires ComboCap and its Dual-Chamber Capsule Technology
    Coatings World

    Latest Breaking News From Coatings World

    PPG Names Rodolfo Ramirez GM, Packaging Coatings
    Sherwin-Williams Unveils High Performance Interior Marine Decking Systems
    AkzoNobel Appoints Ricardo Rosso as Pontiac Site Manager
    Medical Product Outsourcing

    Latest Breaking News From Medical Product Outsourcing

    Apply Now: Junkosha's Technology Innovator of the Year Awards 2023
    SIS Medical's OPN NC PTCA Dilatation Catheter Released in U.S.
    Digital Transformation Weighs Heavy in Medtech Regulatory Performance
    Contract Pharma

    Latest Breaking News From Contract Pharma

    Thermo Fisher, Arsenal Biosciences Partner to Manufacture Autologous T-Cell Therapies
    Aquestive Therapeutics Expands Libervant License/Supply Agreement with Pharmanovia
    OncoVent, Orient EuroPharma Enter License Agreement for Oregovomab
    Beauty Packaging

    Latest Breaking News From Beauty Packaging

    Buttah Skin Founder Wins Emerging Brand Partner of the Year Award from Macy’s
    L’Oréal Wins Legal Battle Over “Paris” Product Labels
    Kosé Taps Shohei Ohtani as Global Ambassador
    Happi

    Latest Breaking News From Happi

    Kao Launches Space Shampoo Sheet for Haircare
    Indie Personal Care and Skincare Brand Indigo Wild Mainstreams Geranium-Patchouli Scent
    Procter & Gamble Brings Tide Relief Project to Mississippi Tornado Victims
    Ink World

    Latest Breaking News From Ink World

    INX International Makes Investment in Gooten
    Videojet Launches 1580 C Soft-Pigmented Contrast Printer
    Epson to Showcase Textile, Signage and Aqueous Printers at ISA 2023
    Label & Narrow Web

    Latest Breaking News From Label & Narrow Web

    Industrias Omega adds Durst Tau RSC E
    Ahlstrom publishes 2022 sustainability report
    INFOFLEX 2023 to feature 20+ press manufacturers
    Nonwovens Industry

    Latest Breaking News From Nonwovens Industry

    SharpCell Launches Plastic-free Airlaid Material for Premium Napkins
    Suominen Offers Biolace Ultrasoft
    Maxcess Offers More Engineering and Converting Solutions for Iberia
    Orthopedic Design & Technology

    Latest Breaking News From Orthopedic Design & Technology

    Collagen Matrix Rebrands to Regenity Biosciences
    OsteoBoost Study Yields Positive Results
    Conventus Flower Ortho Appoints Jeff Culhane as COO
    Printed Electronics Now

    Latest Breaking News From Printed Electronics Now

    Universal Display Sponsors, Presents at ICDT 2023
    Miron Washington Joins Impinj Board of Directors
    All-Time High for Global 300MM Semiconductor Capacity in 2026: SEMI

    Copyright © 2023 Rodman Media. All rights reserved. Use of this constitutes acceptance of our privacy policy The material on this site may not be reproduced, distributed, transmitted, or otherwise used, except with the prior written permission of Rodman Media.

    AD BLOCKER DETECTED

    Our website is made possible by displaying online advertisements to our visitors.
    Please consider supporting us by disabling your ad blocker.


    FREE SUBSCRIPTION Already a subscriber? Login